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38818-50-7

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38818-50-7 Usage

Chemical Properties

powder or crystals

Uses

4-Chloro-3-nitrobenzoyl chloride may be employed as acylation reagent for the Friedel-Crafts acylation of activated benzenes such as anisole, veratrole and 1,4-dimethoxybenzene. It may be employed for the synthesis of 4-chloro-4-methoxy-3-nitrobenzophenone. It may be employed as acylation reagent for the acylation reaction of the deactivated amines (2- aminopyrimidine, aminopyrazine).

General Description

4-Chloro-3-nitrobenzoyl chloride is an acid halide.

Check Digit Verification of cas no

The CAS Registry Mumber 38818-50-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,8,1 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 38818-50:
(7*3)+(6*8)+(5*8)+(4*1)+(3*8)+(2*5)+(1*0)=147
147 % 10 = 7
So 38818-50-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H3Cl2NO3/c8-5-2-1-4(7(9)11)3-6(5)10(12)13/h1-3H

38818-50-7 Well-known Company Product Price

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  • Aldrich

  • (407925)  4-Chloro-3-nitrobenzoylchloride  98%

  • 38818-50-7

  • 407925-25G

  • 407.16CNY

  • Detail

38818-50-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Chloro-3-nitrobenzoyl chloride

1.2 Other means of identification

Product number -
Other names 3-Nitro-4-chlorobenzoic acid chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:38818-50-7 SDS

38818-50-7Relevant articles and documents

Hydrogen-bonded framework structures in 4-[(4-chloro-3-nitrobenzoyl)- hydrazinocarbonyl]pyridinium chloride and N-3,5-dinitrobenzoyl-N′- isonicotinoylhydrazine

Vasconcelos, Thatyana R. A.,De Souza, Marcus V. N.,Wardell, Solange M. S. V.,Wardell, James L.,Low, John N.,Glidewell, Christopher

, p. o222-o226 (2006)

In 4-[(4-chloro-3-nitrobenzoyl)hydrazinocarbonyl]pyridinium chloride, C13H10ClN4O4 -·Cl-, the component ions are linked into a three-dimensional framework structure by a combination of three N-H...Cl and five C-H...O hydrogen bonds. In N-3,5-dinitrobenzoyl-N′- isonicotinoylhydrazine, C13H9-N5O6, the molecules are linked into a three-dimensional framework structure by one N-H...O and three C-H...O hydrogen bonds, augmented by an aromatic π-π stacking interaction.

Synthesis, in silico study and antimicrobial activity of new piperine derivatives containing substituted δ-esters

Barbosa-Filho, José M.,Brandao, Maria C. R.,De Athayde-Filho, Petr?nio F.,Dutra, Thalisson F.,Lima, Edeltrudes O.,Lira, Bruno F.,Neto, Hermes Diniz,Trindade, Emmely O.

, p. 2590 - 2602 (2020/11/18)

A series of fifteen new piperine-derived diesters was synthesized through the substitution reaction between the salt of piperic acid, obtained through piperine basic hydrolysis, with the δ-chloro-esters, obtained through the cleavage of tetrahydrofuran (THF) with acyl chlorides in the presence of ZnCl2. The final compounds were obtained with yields ranging from 50 to 84% and were characterized by infrared (IR) and 1H and 13C nuclear magnetic resonance spectroscopy (NMR). The new compounds were evaluated in silico in regard to their ADME (absorption, distribution, metabolism, and excretion) properties, and in vitro for their antimicrobial activity against bacteria strains (Staphylococcus aureus and Pseudomonas aeruginosas), yeast fungi (Candida albicans and C. tropicalis) and filamentous fungi (Aspergillus fumigatus, A. flavus and A. niger). The results from the in silico studies of Lipinski's rule of five showed that most compounds present good pharmacological possibilities, and the results from in vitro antimicrobial activity showed that 8 of the 15 synthesized compounds displayed antimicrobial activity, inhibiting the growth of 40-80% of tested strains, with a minimum inhibitory concentration (MIC) interval ranging from 1024 to 256 μg mL-1

Preparation method of flubendazole

-

Paragraph 0035, (2018/03/26)

The invention relates to a preparation method of flubendazole. The preparation method comprises the following steps: dropwise adding thionyl chloride into a reaction system taking 4-chloro-3-nitrobenzoic acid and o-dichlorobenzene as solvents, wherein DMF (Dimethyl Formamide) is used as a reaction catalyst; then dropwise adding an acylated reaction solution into a fluorobenzene and aluminum trichloride system and carrying out Friedel-Crafts reaction; adding ammonia water, methane and a Friedel-Crafts product into a closed reactor for carrying out amination reaction; adding aminate, the methaneand a palladium carbon catalyst into a high-pressure hydrogenation reactor for reducing; adding a cyclization agent into a reduced reaction solution from which a catalyst is removed for cyclizing; finally, dropwise adding hydrogen peroxide into the cyclized reaction solution for oxidizing. The preparation method disclosed by the invention has the advantages that firstly, during cyclization reaction, an intermediate has an passivation action of carbonyl, so that the cyclization reaction is smoother and reaction time is greatly shortened; secondly, nitro is reduced by adopting a hydroreductionmethod which has better economic and environment-friendly properties compared with a traditional sulfuration alkaline method; thirdly, the cyclization agent adopts lower-price methyl cyanocarbamate,so that production cost is reduced.

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