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3882-38-0

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3882-38-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3882-38-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,8 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3882-38:
(6*3)+(5*8)+(4*8)+(3*2)+(2*3)+(1*8)=110
110 % 10 = 0
So 3882-38-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H23N/c1-18-11-10-17-9-5-4-8-15(17)16(18)12-13-6-2-3-7-14(13)17/h2-3,6-7,15-16H,4-5,8-12H2,1H3/t15-,16-,17+/m0/s1

3882-38-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Morphinan,17-methyl

1.2 Other means of identification

Product number -
Other names 17-Methylmorphinan

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3882-38-0 SDS

3882-38-0Downstream Products

3882-38-0Relevant articles and documents

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Gates et al.

, p. 1141 ()

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Synthesis and Evaluation of 3-Substituted 17-Methylmorphinan Analogs as Potential Anticonvulsant Agents

Newman, Amy Hauck,Bevan, Kathryn,Bowery, Norman,Tortella, Frank C.

, p. 4135 - 4142 (2007/10/02)

Dextromethorphan (1, (+)-3-methoxy-17-methylmorphinan) demonstrates anticonvulsant activity in a variety of in vitro and in vivo models of convulsive action.It is well known that 1 is metabolized to its phenolic derivative dextrorphan (2) and this metabolite is also a potent anticonvulsant.A series of (+)-3-substituted-17-methylmorphinans, which are structurally similar to 1 but are either not expected to be metabolized to 2 or might do so at a reduced rate, as compared to 1, were prepared.Three analogs, 5 ((+)-3-amino-17-methylmorphinan), 14 ((+)-3-ethoxy-17-methylmorphinan), and 15 ((+)-3-(2-propoxy)-17-methylmorphinan were found to possess potent anticonvulsant activity with full efficacy (ED50 25, 5.6, and 3.9 mg/kg, sc, respectively) in the rat supramaximal electroshock (MES) test.Binding potencies of these compounds to receptor sites labeled with 3H>dextromethorphan (3H>1), in rat brain and guinea pig brain subcellular fractions, and 3H>thienylcyclohexylpiperidine (TCP) and 3H>glycine in rat brain, were determined.Most of the analogs displaced 3H>1 from its binding sites, with compounds 14 (IC50 0.42 μM) and 15 (IC50 0.88 μM having equivalent potencies to 1 (IC50 0.59 μM), in rat brain, and no appreciable activity at the 3H>TCP or 3H>glycine-labeled sites.Compound 5 did not bind with appreciable activity to the 3H>1 site, in rat brain, but did bind to the 3H>TCP site with lower potency than the parent 1 (IC50 7.8 and 2.0 μM, respectively).The mechanism of anticonvulsant action of these agents is not clear although it appears that interaction at the 3H>1 sites may be involved.

MORPHINANS AND 6-KETOMORPHINANS UNSUBSTITUTED IN THE AROMATIC RING. HIGH ANALGESIC ACTIVITY OF (-)-6-KETO-N-METHYLMORPHINAN, IV.

Schmidhammer, Helmut,Jacobson, Arthur E.,Brossi, Arnold

, p. 391 - 394 (2007/10/02)

Elimination of the phenolic hydroxy group from (-)-4-hydroxy-6-keto-N-methylmorphinan (1) afforded the morphinan ketone 3 which was several times more potent as an analgesic than morphine.Removal of the carbonyl group in 3 by a Wolff-Kishner reduction gave the unsubstituted morphinan 7 which was only half as potent as morphine.

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