3883-34-9

Basic information

• Product Name: C₂₂H₂₃NO
• Synonyms: C₂₂H₂₃NO
• CAS NO: 3883-34-9
• Molecular Weight: 317.431
• Mol File: 3883-34-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₃NO(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₃NO(3883-34-9)
• EPA Substance Registry System: C₂₂H₂₃NO(3883-34-9)

Safety Data

• Hazardous Substances Data: 3883-34-9(Hazardous Substances Data)

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 102756-58-1 1-methyl-3,5-bis-(4-methyl-benzyl)-1H-pyridin-4-one 
• 1174000-38-4 8-(4-methylbenzylidene)-2-amino-4-(4-methylphenyl)-5,6,7,8-tetrahydro-6-methyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile 
• 1174000-22-6 2-amino-5,6,7,8-tetrahydro-6-methyl-8-(4-methylbenzylidene)-4-(4-methylphenyl)-1,6-naphthyridine-3-carbonitrile 
• 1289514-32-4 (4R,8E)-2-amino-5,6,7,8-tetrahydro-6-methyl-4-(4-methylphenyl)-8-(4-methylphenylmethylene)-4H-pyrano[3,2-c]pyridine-3-carbonitrile 

Relevant articles and documents

Synthesis and molecular modeling studies of indole-based antitumor agents

Indole-based compounds 30-63 were synthesized by the multi-component 1,3-dipolar cycloaddition reaction of 1-alkyl-3,5-bis(arylidene)-4-piperidones 11-25 with azomethine ylides (generated by the condensation of isatins 26-28 with sarcosine 29). The single crystal X-ray studies of 46 and 48 supported the regio- and stereoselectivity of the reaction. Most of the synthesized spiro-indoles exhibited potent antitumor properties against the HeLa (cervical cancer) cell line through in vitro sulfo-rhodamine-B bioassay, higher than that of cisplatin. Only compound 54 showed bio-potency against the HepG2 (hepatocellular cancer) cell line, comparable to that of doxorubicin hydrochloride (standard reference). 3D-Pharmacophore and 2D-QSAR studies were used to validate the observed biological data and determine the most important parameters controlling activity. The estimated bio-properties from the computational studies showed high approximations to the experimental data.

Microwave accelerated facile and efficient synthesis of piperido[3′,4′:5,6]pyrano[2,3-d] pyrimidinones catalyzed by basic ionic liquid [BMIM]OH

A basic ionic liquid [BMIM]OH could very efficiently catalyze the synthesis of piperido[3′,4′:5,6]pyrano[2,3-d]pyrimidinone derivatives from pyrano[3,2-c]piperidine analogues and carbonyl compounds. [BMIM]OH acted as a catalyst as well as the reaction medium and could be used for the reactions for five times without any appreciable loss of its catalytic efficiency. The synergic couple of microwave and ionic liquid provided high yields of the product in very short reaction times and allowed easy workup.

Magnetic graphene oxide anchored sulfonic acid as a novel nanocatalyst for the synthesis of N-aryl-2-amino-1,6-naphthyridines

Magnetic graphene oxide functionalized with sulfonic acid (Fe 3O4-GO-SO3H) was used as a new recyclable nanocatalyst for one-pot synthesis of N-aryl-2-amino-1,6-naphthyridine derivatives under solvent free conditions. The catalyst could be easily recovered from the reaction mixture by an external magnet and reused without significant decrease in activity even after 4 runs. This nanocatalyst exhibited better activities to other commercially available sulfonic acid catalysts.