38847-55-1

Upstream product

• 38846-08-1 4,4-dimethyl-3-dimethylamino-1-phenylhex-5-en-1-yne 
• 10345-87-6 3-phenylcyclohex-2-enone 
• 74-88-4 methyl iodide 
• 1073-13-8 4,4-dimethylcyclohexenone 
• 221551-43-5 4,4-dimethyl-1-phenylcyclohex-2-en-1-ol 
• 415896-24-1 1-(trimethylsilyl)-3,3-dimethyl-6-phenyl-5-hexyn-2-one 
• 182809-45-6 methyl 2,2-dimethyl-5-phenylpent-4-ynoate 
• 21541-60-6 3-phenylprop-2-ynyl 4-methylbenzenesulfonate 
• 233664-98-7 2-(trimethylsilyloxy)-3,3-dimethyl-6-phenyl-1-hexen-5-yne 
• 591-51-5 phenyllithium 

Relevant academic research and scientific papers

Arene Trifunctionalization with Highly Fused Ring Systems through a Domino Aryne Nucleophilic and Diels–Alder Cascade

A convenient and efficient domino aryne process was developed under transition-metal-free conditions to generate a range of tetra- and pentacyclic ring systems. This transformation was realized via a 1,2-benzdiyne through a nucleophilic and Diels–Alder reaction cascade using styrene as the diene moiety. Three new chemical bonds, namely one C?N and two C?C bonds, and two benzofused rings could be constructed concomitantly, which was made possible by distinct chemoselective control at both the 1,2-aryne and 2,3-aryne stages. Moreover, in-depth studies were carried out on the domino aryne precursors and controlling the diastereoselectivity.

Palladium-catalyzed oxidative rearrangement of tertiary allylic alcohols to enones with oxygen in aqueous solvent

A one-pot procedure for Pd(TFA)2-catalyzed 1,3-isomerization of tertiary allylic alcohols to secondary allylic alcohols followed by a Pd(TFA)2/neocuproine-catalyzed oxidative reaction to β-disubstituted-α,β-unsaturated kenones was developed. (Chemical Equation Presented).

IBS-catalyzed oxidative rearrangement of tertiary allylic alcohols to enones with oxone

A 2-iodoxybenzenesulfonic acid (IBS)-catalyzed oxidative rearrangement of tertiary allylic alcohols to enones with powdered Oxone in the presence of potassium carbonate and tetrabutylammonium hydrogen sulfate has been developed.

Lewis acid-mediated intramolecular addition of silyl enol ethers to internal unactivated alkynes

The EtAlCl2-mediated intramolecular addition of silyl enol ethers to both terminal and internal unactivated alkynes, bearing alkyl and phenyl susbstituents at the alkyne moiety, gave mono- and bicyclic β,γ-unsaturated ketones in good to excelle

The first addition of silyl enol ethers to internal unactivated alkynes

The EtAlCl2-mediated intramolecular addition of silyl enol ethers to both terminal and internal unactivated alkynes, bearing alkyl and phenyl susbstituents at the alkyne moiety, proceeded exclusively in the endo- fashion to give mono- and bicyc

Double ring-opening reactions of bis-cyclopropanes promoted by iron salts

Certain bis-cyclopropanes were prepared from the corresponding dienol silane and, on treatment with ferric salts, were found to undergo two sequential C-C bond cleavages to give products corresponding to overall two carbon ring-expansion. In one case the nature of the product obtained was found to depend upon the types of ferric salts employed.

Base Catalysed Rearrangements involving Ylide Intermediates. Part 5. Thermal Rearrangements of 3-Dimethylaminohex-5-en-1-ynes

Thermal rearrangements of 3-dimethylaminohex-5-en-1-ynes (5) yield biphenyls (6).The mechanism of the transformation (5) -> (6) involves a sequence of (i) a sigmatropic rearrangement, (ii) a hydrogen shift, (iii) an electrocyclic reaction, and (iv) elimination of dimethylamine (Scheme 2).

Base-catalysed rearrangement of allyl-propynyl ammonium cations and a novel synthetic route to substituted biphenyls

Base-catalysed rearrangement of the salts (I) in aprotic media gives the amines (II) and (III); the amines (II) on heating yield the biphenyl derivatives (V).