3885-76-5Relevant academic research and scientific papers
Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT3 ligands
Iriepa, Isabel,Villasante, Francisco J.,Galvez, Enrique,Labeaga, Luis,Innerarity, Ana,Orjales, Aurelio
, p. 189 - 192 (2007/10/03)
A series of 4-amino-5-chloro-2-methoxybenzoates and benzamides containing the 5- and 6-isoquinuclidinyl system was synthesised and evaluated for binding to 5-HT3, 5-HT4 and D2 receptors. In general, the isoquinuclidine derivatives at the 5-position have shown to be more potent as 5-HT3 ligands but they also possess 5-HT4 and D2 properties. However, the results show that the derivatives at the 6-position afforded the most promising compounds in terms of both receptor affinity and selectivity.
Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
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, (2008/06/13)
Compounds of the formula STR1 wherein R1 is hydrogen, C1 -C6 alkyl, or a pharmaceutically acceptable cation; Y is cyclopropyl, ethyl or p-fluorophenyl, and X is hydrogen or fluoro, or X and Y taken together form a group ST
Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
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, (2008/06/13)
Compounds of the formula wherein R1 is hydrogen, C1-C6 alkyl, or a pharmaceutically acceptable cation;, Y is cyclopropyl, ethyl or p-fluorophenyl, and X is hydrogen or fluoro, or X and Y taken together form a group wherein R3 is hydr
Regioselective Synthesis of Isoquinuclidin-6-ones. Synthesis of an Ibogamine Intermediate
Krow, Grant R.,Shaw, Donald A.,Lynch, Barton,Lester, Walden,Szczepanski, Steven W.,Raghavachari, Ramesh
, p. 2258 - 2262 (2007/10/02)
Addition of benzeneselenenyl chloride to 5,6-dehydroisoquinuclidines 8 followed by dehydrohalogenation and hydrolysis of the derived vinyl selenides 11 affords isoquinuclidin-6-ones 7 regioselectively.The method has been applied to the synthesis of 7-syn-ethylisoquinuclidin-6-one 16, an intermediate in the synthesis of ibogamine 2a.
