38857-88-4

Basic information

• Product Name: BIS(2,2,2-TRICHLOROETHYL) AZODICARBOXYLATE
• Synonyms: AZODICARBOXYLIC ACID BIS(2,2,2-TRICHLOROETHYL) ESTER;BIS(2,2,2-TRICHLOROETHYL) AZODICARBOXYLATE;BIS(2,2,2-TRICHLOROETHYL) AZODI-CARBOXYL ATE, 97+%;Bis(2,2,2-trichloroethyl) azodicarboxyle;BEAZ Bis(2,2,2-trichloroethyl) azodicarboxylate
• CAS NO: 38857-88-4
• Molecular Formula: C₆H₄Cl₆N₂O₄
• Molecular Weight: 380.82
• Mol File: 38857-88-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 109-111 °C(lit.)
• Boiling Point: 380.7°C at 760 mmHg
• Flash Point: 184.1°C
• Appearance: /
• Density: 1.78g/cm³
• Vapor Pressure: 5.34E-06mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• BRN: 2141527
• CAS DataBase Reference: BIS(2,2,2-TRICHLOROETHYL) AZODICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(2,2,2-TRICHLOROETHYL) AZODICARBOXYLATE(38857-88-4)
• EPA Substance Registry System: BIS(2,2,2-TRICHLOROETHYL) AZODICARBOXYLATE(38857-88-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 38857-88-4(Hazardous Substances Data)

Usage

Chemical Properties

Yellow powder or crystals

Uses

Bis(2,2,2-trichloroethyl) azodicarboxylate has been used:in the asymmetric synthesis of substituted cycloalkyl[b]indolesas amination reagent during the aza-ene reaction of different alkenes to yield the corresponding allyl aminesin para-directed amination of C2-alkyl substituted anisolein the synthesis of acid- and base-sensitive azo compounds and in Diels-Alder cycloadditions

General Description

Thermal inverse-type hetero-Diels-Alder reaction of O-silyl-protected lactal and bis(2,2,2-trichloroethyl) azodicarboxylate has been reported.

InChI:InChI=1/C6H4Cl6N2O4/c7-5(8,9)1-17-3(15)13-14-4(16)18-2-6(10,11)12/h1-2H2/b14-13+

Upstream product

• 38858-02-5 bis(2,2,2-trichloroethyl) hydrazino-1,2-dicarboxylate 

Downstream Products

• 98760-57-7 bis(2,2,2-trichloroethyl) 3,6-diphenyl-1,2,3,6-tetrahydropyridazine-1,2-dicarboxylate 
• 1231976-79-6 C₃₂H₃₀Cl₆N₄O₈S 
• 148678-87-9 1-(4-hydroxyphenyl)-1,2-hydrazinedicarboxylic acid bis(2,2,2-trichloroethyl) ester 
• 154876-10-5 1-(4-methoxy-2-methylphenyl)-1,2-hydrazinedicarboxylic acid bis(2,2,2-trichloroethyl) ester 
• 132408-69-6 1-(2-cyclohexen-1-yl)-1,2-hydrazinedicarboxylic acid bis(2,2,2-trichloroethyl) ester 
• 148678-89-1 1-(2,4-dimethoxyphenyl)-1,2-hydrazinedicarboxylic acid bis(2,2,2-trichloroethyl) ester 
• 154876-11-6 1-(2,4-dimethylphenyl)-1,2-hydrazinedicarboxylic acid bis(2,2,2-trichloroethyl) ester 
• 148678-86-8 1-(4-methoxyphenyl)-1,2-hydrazinedicarboxylic acid bis(2,2,2-trichloroethyl) ester 
• 87656-02-8 N,N'-Bis<(2,2,2-trichloroethoxy)carbonyl>-7-<(E)-6-<(8-phenylcarbomenthyl)oxy>-3,3-dimethyl-5-hexenylidene>-2,3-diazabicyclo<2.2.1>heptane 
• 87681-11-6 N,N'-Bis<(2,2,2-trichloroethoxy)carbonyl>-7-<(E)-6-(carbomenthoxy)-3,3-dimethylhex-5-enylidene>-2,3-diazabicyclo<2.2.1>heptane 
• 148678-92-6 C₂₇H₂₃BrCl₆N₂O₇ 

Relevant articles and documents

Rh(I)-catalyzed carbonylative ring opening of diazabicycles with acyl anion equivalents

A catalytic desymmetrization of strained alkenes by ring-opening of meso-diazabicycles with acyl anion nucleophiles is reported. Densely functionalized frans-1,2-hydrazinoacyl cyclopentene building blocks are obtained stereoselectively. The acyl anion equ

Novel Heteroarotinoids as Potential Antagonists of Mycobacterium bovis BCG

A series of 15 heteroarotinoids has been prepared and evaluated for activity against Mycobacterium bovis BCG with the thiourea-containing isoxyl (7) (0.5 μg/mL) as the standard. 2,2,4-Trimethyl-2H-chromen-7-yl 4-(methoxycarbonyl)benzoate (8) displayed the most significant activity (2.0-4. 0 μg/mL) in terms of the lowest concentration (μg/mL) (MIC, minimum inhibitory concentration) required to produce a 99% reduction in the number of colonies on a plate as compared to that system free of the agent at the same dilution of the culture suspension. Ethyl 4-{[N-(2,2,4,4-tetramethylchroman-6-yl)thiocarbamoyl]amino}benzoate (9) and [(1E,3Z,5E)-1-aza-4-methyl-6-(1,2,2,4-tetramethyl(1,2-dihydroquinolyl))hexa-1,3, 5-trienyl]amino}aminomethane-1-thione (10) exhibited activity at 5.0-10.0 and 10.0-20.0 μg/mL, respectively, while the other examples had MIC values of 20 μg/mL or greater. The inhibitory ability of 8 may occur via the inhibition of mycolic acid synthesis in a like manner as found with 7, but this requires further study. The heteroarotinoids are the first examples to exhibit inhibitory ability against the growth of Mycobacterium bovis BCB.

Bis(2,2,2-trichloroethyl) azodicarboxylate

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