388574-66-1

Upstream product

• 4857-06-1 2-chloro-1H-benzoimidazole 
• 85118-01-0 alpha-bromo-3,4-difluorotoluene 

Downstream Products

• 388575-18-6 [10-(3,4-difluoro-benzyl)-3,4-dioxo-3,4-dihydro-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-2-yl]-acetic acid ethyl ester 
• 388575-06-2 10-(3,4-difluoro-benzyl)-2,10-dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazine-3,4-dione 
• 388574-86-5 [1-(3,4-difluoro-benzyl)-1H-benzoimidazol-2-yl]-hydrazine 

Relevant academic research and scientific papers

PHARMACEUTICAL COMPOSITIONS

This invention provides pharmaceutical compositions comprising therapeutically effective amounts of a monoamine reuptake inhibitor and an SK inhibitor. In another aspect the invention provides novel benzoimidazole derivatives for use according to the inve

NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS

This invention relates to novel 2-amino benzimidazole derivatives of formula (I1) and (Ib) useful as modulators of small-conductance calcium-activated potassium channels (SK channels) . In other aspects the invention relates to the use of these compounds

[1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: A new class of selective aldose reductase inhibitors

Acetic acid derivatives of [1,2,4]triazino[4,3-a]benzimidazole (TBI) were synthesized and tested in vitro and in vivo as a novel class of aldose reductase (ALR2) inhibitors. Compound 3, (10-benzyl[1,2,4]triazino[4,3-a]benzimidazol-3,4(10H)-dion-2-yl)aceti