388574-83-2

Upstream product

• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 4857-06-1 2-chloro-1H-benzoimidazole 
• 84946-20-3 2-chloro-1-(4-fluorobenzyl)-1H-benzimidazole 

Downstream Products

• 388575-02-8 10-(4-fluoro-benzyl)-2,10-dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazine-3,4-dione 
• 388575-16-4 [10-(4-fluoro-benzyl)-3,4-dioxo-3,4-dihydro-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-2-yl]-acetic acid ethyl ester 
• 1632303-84-4 9-(4-fluorobenzyl)-3-phenyl-9H-benzo[4,5]imidazo[2,1-c][1,2,4]triazole 
• 1632303-85-5 3-(((tert-butyldimethylsilyl)oxy)methyl)-9-(4-fluorobenzyl)-9H-benzo[4,5]imidazo[2,1-c][1,2,4]triazole 
• 1632303-86-6 3-(tert-butyl)-9-(4-fluorobenzyl)-9H-benzo[4,5]imidazo[2,1-c][1,2,4]triazole 

Relevant academic research and scientific papers

Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4-Oxadiazole Motifs

Azomethine-linked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4-oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR,1H-NMR,13C-NMR, and elemental analysis. Evaluation for the cytotoxic activities in vitro against a panel of breast cancer cell lines (MDA-AB-231, BT-474, and Ishikawa cells) revealed that the pyrrole–benzimidazole hybrids are more potent than the pyrazolone and 1,3,4-oxadiazole hybrids in all cell lines. Compound 9 displayed promising cytotoxicity against BT-474 cell line with IC50values, 7.7 μM.

[1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: A new class of selective aldose reductase inhibitors

Acetic acid derivatives of [1,2,4]triazino[4,3-a]benzimidazole (TBI) were synthesized and tested in vitro and in vivo as a novel class of aldose reductase (ALR2) inhibitors. Compound 3, (10-benzyl[1,2,4]triazino[4,3-a]benzimidazol-3,4(10H)-dion-2-yl)aceti