388591-55-7Relevant academic research and scientific papers
Antiproliferative and tumor inhibitory studies of 2,3 disubstituted 4-thiazolidinone derivatives
Sharath Kumar, Kothanahally S.,Hanumappa, Ananda,Vetrivel, Maruthai,Hegde, Mahesh,Girish, Yarabhally R.,Byregowda, Thinnali R.,Rao, Suguna,Raghavan, Sathees C.,Rangappa, Kanchugarakoppal S.
, p. 3616 - 3620 (2015)
Abstract 4-Thiazolidinone derivatives were synthesized using T3P-DMSO media as a cyclodehydrating agent. All the molecules were tested for their cytotoxicity against leukemic cell lines. The compound 3-(4-bromophenyl)-2-(4-(dimethylamino)phenyl)thiazolidin-4-one (4e) with electron donating substituent at para position of phenyl ring displayed considerable cytotoxicity against Reh and Nalm6 cells with an IC50 value of 11.9 and 13.5 μM, respectively. Furthermore, the compound 4e tested for tumor regression studies induced by EAC in Swiss albino mouse. Both in vitro and in vivo results suggested significant antiproliferative activity of compound 4e in Reh cells and mouse tumor tissue treated with compound 4e showed multifocal areas of necrosis and numerous number of apoptotic cells.
T3P-DMSO mediated one pot cascade protocol for the synthesis of 4-thiazolidinones from alcohols
Sharath Kumar, Kothanahally S.,Swaroop, Toreshettahally R.,Harsha, Kachigere B.,Narasimhamurthy, Kereyagalahally H.,Rangappa, Kanchugarakoppal S.
, p. 5619 - 5623 (2012/10/29)
Propylphosphonic anhydride (T3P)-DMSO mediated oxidation of alcohols to carbonyl compounds and their subsequent cyclization with aryl/hetero aryl amines and thioglycolic acid to afford 4-thiazolidinones has been reported. Synthesis of 4-thiazolidinones di
