388601-34-1Relevant academic research and scientific papers
Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists
Xiang, Min Amy,Chen, Robert H.,Demarest, Keith T.,Gunnet, Joseph,Look, Richard,Hageman, William,Murray, William V.,Combs, Donald W.,Patel, Mona
, p. 2987 - 2989 (2007/10/03)
A novel series of spirobenzazepines was synthesized and evaluated for V1a and V2 receptor antagonist activity. Compounds 8b, 8i, and 8k have shown selective V1a receptor antagonist activity. Compounds 8p and 8q were shown to be dual V1a/V2 receptor antagonists.
Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
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, (2008/06/13)
The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, n, R1, R2, R3, R4, R5, a and b are as described in the specification, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
