388621-95-2Relevant academic research and scientific papers
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications
Lee,Marquez,Han,Kang,Pearce,Lewin,Yan,Benzaria,Nicklaus,Blumberg
, p. 4309 - 4312 (2001)
An approach to reduce the log P in a series of diacylglycerol (DAG)-lactones known for their high binding affinity for protein kinase C (PK-C) is presented. Branched alkyl groups with reduced lipophilicity were selected and combined with the replacement o
