388633-53-2Relevant academic research and scientific papers
Use of an aminooxy linker for the functionalization of oligodeoxyribonucleotides
Defrancq, Eric,Lhomme, Jean
, p. 931 - 933 (2001)
We describe the preparation of oligonucleotides containing a 5′-linker bearing an aminooxy group. Use of the trityl protecting group for the aminooxy moiety allows purification of the modified oligonucleotide by reverse phase HPLC and cleavage in mild aci
Highly efficient synthesis of peptide-oligonucleotide conjugates: Chemoselective oxime and thiazolidine formation
Forget, Damien,Boturyn, Didier,Defrancq, Eric,Lhomme, Jean,Dumy, Pascal
, p. 3976 - 3984 (2007/10/03)
A convergent strategy for the synthesis of peptide-oligonucleotide conjugates (POC) is presented. Chemoselective ligation of peptide to oligonucleotide was accomplished by oxime and thiazolidine formation. Oxime conjugation was performed by treating an ox
