38873-82-4

Basic information

• Product Name: 15(R)-PROSTAGLANDIN E2
• Synonyms: 15(R)-PROSTAGLANDIN E2;15-EPI PGE2;9-OXO-11ALPHA,15R-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;XEYBRNLFEZDVAW-GKEZHNTDSA-N
• CAS NO: 38873-82-4
• Molecular Formula: C20H32O5
• Molecular Weight: 352.47
• Mol File: 38873-82-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 15(R)-PROSTAGLANDIN E2(CAS DataBase Reference)
• NIST Chemistry Reference: 15(R)-PROSTAGLANDIN E2(38873-82-4)
• EPA Substance Registry System: 15(R)-PROSTAGLANDIN E2(38873-82-4)

Safety Data

• Hazardous Substances Data: 38873-82-4(Hazardous Substances Data)

Usage

Uses

15(R)?-?Prostaglandin E2 is a prostaglandins in the gorgonian Plexaura homomalla. 15(R)?-?Prostaglandin E2 isan isomeric compound of Prostaglandin E2(P838610). Prostaglandin E2 is the most common and biologically potent of mammalian prostaglandins. Oxytocic; abortifacient.

Upstream product

• 39746-01-5 (1S,5R,6R,7R)-6-formyl-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one 
• 303015-42-1 ethyl (5Z,8R,9R,11S,12S,13E,15R)-9-acetoxy-11,15-bis-(tert-butyldimethylsilyloxy)prosta-5,13-dienoate 
• 303015-43-2 (5Z,8R,9R,11S,12S,13E,15R)-11,15-bis-(tert-butyldimethylsilyloxy)-9-hydroxyprosta-5,13-dienoic acid 
• 214748-78-4 (Z)-7-[(1R,2S,3S,5R)-5-Acetoxy-3-hydroxy-2-((E)-(R)-3-hydroxy-oct-1-enyl)-cyclopentyl]-hept-5-enoic acid ethyl ester 
• 303015-41-0 (5Z,8R,9R,11S,12S,13E,15R)-11,15-bis-(tert-butyldimethylsilyloxy)-9-oxoprosta-5,13-dienoic acid 
• 851542-07-9 (Z)-7-{(1R,2R,3R,5S)-2-[(E)-(R)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-hydroxy-3-triethylsilanyloxy-cyclopentyl}-hept-5-enoic acid methyl ester 
• 851542-06-8 (2R,3aR,4R,5R,6aS)-4-[(E)-(R)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-triethylsilanyloxy-hexahydro-cyclopenta[b]furan-2-ol 
• 851542-05-7 (1S,2R,3R,4R)-3-[(E)-(R)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-(2-hydroxy-ethyl)-4-triethylsilanyloxy-cyclopentanol 
• 851542-04-6 (3aR,4R,5R,6aS)-4-[(E)-(R)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-triethylsilanyloxy-hexahydro-cyclopenta[b]furan-2-one 
• 851542-08-0 (Z)-7-{(1R,2R,3R,5S)-2-[(E)-(R)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-3,5-dihydroxy-cyclopentyl}-hept-5-enoic acid methyl ester 
• 851542-03-5 Benzoic acid (3aR,4R,5R,6aS)-4-[(E)-(R)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 
• 137625-91-3 (3aR,4R,5R,6aS)-4-[(E)-(R)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-hydroxy-hexahydro-cyclopenta[b]furan-2-one 
• 40834-86-4 (3aR,4R,5R,6aS)-benzoic acid 2-oxo-4-[(1E)-3-oxo-oct-1-enyl]-hexahydro-cyclopenta[b]furan-5-yl ester 
• 51705-58-9 [3aR,4R(1E,3R),5R,6aS]-5-benzoyloxy-4-(3-hydroxyocten-1-yl)-hexahydro-2H-cyclopenta[b]furan-2-one 

Downstream Products

• 23453-26-1 (+/-)-prostaglandin E₂ methyl ester 

Relevant articles and documents

Synthesis of 15R-PGD2: A potential DP2 receptor agonist

The first total synthesis of 15R-PGD2 3 was accomplished. The approach used in this report is also an efficient method to produce 15R-PGE 2. 15R-PGD2, a potential DP2 receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory diseases.

Racemic fluoro-substituted PGF2 α analogs

This invention is racemic PGE2, racemic PGF2α, racemic PGF2β, racemic PGA2, racemic PGB2, analogs of those, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibiton of platelet aggregation, increase of nasal patency, abortion, and wound healing.

Racemic prostaglandins of the 2-series and analogs thereof

This invention is racemic PGE2, racemic PGF2α, racemic PGF2β , racemic PGA2, racemic PGB2, analogs of those, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, abortion, and wound healing.