38876-62-9Relevant academic research and scientific papers
In silico design, synthesis, and screening of novel deoxyhypusine synthase inhibitors targeting HIV-1 replication
Schroeder, Marcus,Kolodzik, Adrian,Pfaff, Katharina,Priyadarshini, Poornima,Krepstakies, Marcel,Hauber, Joachim,Rarey, Matthias,Meier, Chris
, p. 940 - 952 (2014/05/20)
The human enzyme deoxyhypusine synthase (DHS) is an important host cell factor that participates in the post-translational hypusine modification of eukaryotic initiation factor 5A (eIF-5A). Hypusine-modified eIF-5A plays a role in a number of diseases, in
Aminocarbonylations employing Mo(CO)6 and a bridged two-vial system: Allowing the use of nitro group substituted aryl iodides and aryl bromides
Nordeman, Patrik,Odell, Luke R.,Larhed, Mats
, p. 11393 - 11398 (2013/02/23)
A bridged two-vial system aminocarbonylation protocol where Mo(CO) 6 functions as an external in situ solid source of CO has been developed. For the first time both nitro group containing aryl/heteroaryl iodides and bromides gave good to excellent yields in the Mo(CO) 6-mediated and palladium(0)-catalyzed conversion to benzamides, while the identical one-vessel protocol afforded extensive reduction of the nitro functionality. The above-mentioned bridged two-compartment protocol furnished good results with both primary amines and secondary amines and sluggish aniline nucleophiles at 65-85 C reaction temperatures.
