3888-61-7

Usage

Structure

Substituted diene compound with a central butadiene unit and two 4-fluorophenyl groups attached

Type of compound

Conjugated diene with alternating single and double bonds

Common use

Building block in the synthesis of various organic compounds

Application

Organic synthesis, development of pharmaceuticals and agrochemicals

Reactivity

Useful in organic synthesis due to its properties

Structural features

Unique structural features make it a valuable tool in the study of organic chemistry and the development of new materials.

Upstream product

• 439599-16-3 2,2-bis(4-fluorophenyl)-1-methylenecyclopropane 
• 106-95-6 allyl bromide 
• 772-31-6 cyclopropyl(4-fluorophenyl)methanone 
• 802257-07-4 4-Dimethylamino-1,1-bis-<4-fluor-phenyl>-butanol-(1) 
• 685077-69-4 4-Dimethylamino-1,1-bis-<4-fluor-phenyl>-buten-(1) 
• 1356251-77-8 C₁₇H₁₇FN₂O₂S 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 345-92-6 4,4'-Difluorobenzophenone 

Downstream Products

• 1556997-71-7 2-[2,2-bis(4-fluorophenyl)ethenyl]-3,5-dihydro-5-methylfuro[3,2-c]quinolin-4(2H)-one 
• 1556998-00-5 2-[2,2-bis(4-fluorophenyl)ethenyl]-6,6-dimethyl-2,3,6,7-tetrahydrobenzofuran-4(5H)-one 

Relevant academic research and scientific papers

Pd(0)-catalyzed cross-coupling of allyl halides with α-diazocarbonyl compounds or N-mesylhydrazones: Synthesis of 1,3-diene compounds

With palladium catalysis, allyl bromides or chlorides react with α-diazocarbonyl compounds or N-mesylhydrazones to afford 1,3-diene derivatives. The reaction represents a novel and efficient method for the synthesis of 1,3-butadiene derivatives. Mechanist

Palladium-catalyzed cross-coupling of cyclopropylmethyl N-tosylhydrazones with aromatic bromides: An easy access to multisubstituted 1,3-butadienes

Direct synthesis of 1,1-disubstitued 1,3-butadienes has been efficiently realized from the cross-coupling of cyclopropylmethyl N-tosylhydrazones with aromatic bromides by means of PdCl2(MeCN)2 as catalyst. 1,1,4-Trisubstitued 1,3-but

Cyclopropylmethyl palladium species from carbene migratory insertion: New routes to 1,3-butadienes

Cyclopropylmethyl palladium species can be accessed by Pd-catalyzed reaction of either cyclopropyl N-tosylhydrazone with halide or N-tosylhydrazone with cyclopropyl halide. In both approaches migratory insertion of Pd carbene is the key process. These transformations constitute new approaches toward 1,3-butadiene derivatives.

Selective C-C bond activation of 2-aryl-1-methylenecyclopropanes promoted by Ir(I) and Rh(I) hydrido complexes. Mechanism of ring-opening isomerization of the strained molecules

[IrH(CO)(PPh3)3] promotes ring opening of 2-phenyl-1-methylenecyclopropane at room temperature to produce the Ir complex with a chelating 2-phenyl-3-butenyl ligand, [Ir{η2-CH 2CH(Ph)CH=CH2-κC1/s

Palladium-catalyzed isomerization of methylenecyclopropanes in acetic acid

PD(PPh3)4-catalyzed isomerization of MCPs 1 in acetic acid proceeds smoothly at 80 °C in toluene to give the corresponding I-substituted or 1,1-disubstituted dienes 2 in good to excellent yields under mild conditions. The plausible mechanism has been disclosed on the basis of a deuterium-labeling experiment.