38896-18-3

Upstream product

• 1007-26-7 (2,2-dimethyl-1-propyl)benzene 
• 38896-17-2 N-(4-neopentylphenyl)acetamide 

Downstream Products

• 38896-19-4 4-neopentyl-2-nitrobenzenamine 
• 1449475-58-4 4-neopentylbenzene-1,2-diamine 
• 1449475-60-8 (S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate 
• 144146-99-6 1-iodo-4-neopentyl-2-nitrobenzenamine 

Relevant academic research and scientific papers

BENZIIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AS SODIUM CHANNEL MODULATORS

The invention relates to benzimidazole and imidazopyridine derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new Nav1.8 modulators of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7. X and Y are as defined in the description. Nav1.8 modulators are potentially useful in the treatment of a wide range of disorders, particularly pain.

An N.M.R. Investigation of Ground-State Polarization of Some Substituted Aromatic Systems

The previously established n.m.r. method for estimating mobile bond orders was applied to the investigation of ground-state polarization of benzene derivatives with ortho or para pairs of +R/-R substituents, naphthalene and five heteroaromatic systems (furan, thiophen, pyrrole, quinoline and pyrazole).Evidence for significant ground-state polarization which is solvent-independent was found in a number of these systems, especially benzene, pyrrole and pyrazole.