389064-25-9

Basic information

• Product Name: Proteasome Inhibitor XVI
• Synonyms: Proteasome Inhibitor XVI
• CAS NO: 389064-25-9
• Molecular Formula: C50H88N6O8S
• Molecular Weight: 933.33
• Mol File: 389064-25-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1161.4±65.0 °C(Predicted)
• Appearance: /
• Density: 1.096±0.06 g/cm3(Predicted)
• Storage Temp.: -20C
• PKA: 13.41±0.46(Predicted)
• CAS DataBase Reference: Proteasome Inhibitor XVI(CAS DataBase Reference)
• NIST Chemistry Reference: Proteasome Inhibitor XVI(389064-25-9)
• EPA Substance Registry System: Proteasome Inhibitor XVI(389064-25-9)

Safety Data

• Hazardous Substances Data: 389064-25-9(Hazardous Substances Data)

Usage

Description

Proteasome Inhibitor XVI is a cell-permeable, peptide vinyl sulfone that serves as a potent and irreversible inhibitor of proteasome activity. It covalently modifies the catalytically active β-subunits of the proteasome, thereby inhibiting its function. This inhibitor has been shown to effectively suppress the chymotrypsin-like, trypsin-like, and peptidyl glutamyl peptide hydrolyzing (PGPH) activities of purified 20S proteasomes from rabbit muscle. Additionally, it inhibits the proteasomal degradation of deglycosylated MHC HLA-A2 heavy chain in US11+ cells.

Uses

Used in Pharmaceutical Industry:
Proteasome Inhibitor XVI is used as a therapeutic agent for the treatment of various diseases, particularly those involving the ubiquitin-proteasome system. Its ability to inhibit proteasome activity can lead to the accumulation of proteins targeted for degradation, which may have potential applications in the treatment of cancer, neurodegenerative diseases, and autoimmune disorders.
Used in Research Applications:
In the field of research, Proteasome Inhibitor XVI is used as a valuable tool for studying the role of the proteasome in cellular processes. It can help researchers understand the mechanisms underlying protein degradation, cellular signaling, and the regulation of various cellular pathways. This knowledge can be crucial for the development of novel therapeutic strategies and the identification of new drug targets.
Used in Drug Development:
Proteasome Inhibitor XVI can be employed in the development of new drugs targeting the proteasome, which plays a critical role in various cellular processes. By inhibiting the proteasome, this compound can potentially be used to develop therapies that modulate protein homeostasis and interfere with the progression of diseases associated with the dysregulation of the ubiquitin-proteasome system.
Used in Drug Delivery Systems:
Similar to gallotannin, Proteasome Inhibitor XVI can also benefit from novel drug delivery systems to enhance its applications and efficacy. Utilizing carriers such as organic and metallic nanoparticles can improve the delivery, bioavailability, and therapeutic outcomes of Proteasome Inhibitor XVI, making it a more effective treatment option for various diseases.

Biochem/physiol Actions

Cell permeable: yes