389068-26-2

Upstream product

• 107-06-2 1,2-dichloro-ethane 
• 536-74-3 phenylacetylene 
• 29415-97-2 methyl 3-bromo-4-hydroxybenzoate 
• 14900-39-1 phenylvinylboronic acid 

Downstream Products

• 389068-27-3 4-benzyloxy-3-(1-phenyl-vinyl)-benzoic acid-methylester 
• 1275593-43-5 (S)-methyl 4-hydroxy-3-(1-phenylethyl)benzoate 
• 1275593-50-4 (S)-methyl 3-(1-phenylethyl)benzoate 
• 1275593-52-6 (S)-methyl 3-(1-phenylethyl)-4-(trifluoromethyl sulfonyloxy)benzoate 

Relevant academic research and scientific papers

Highly enantioselective hydrogenation of styrenes directed by 2′-hydroxyl groups

A new synthetic strategy that turns styrene-type olefins into excellent substrates for Rh-catalyzed asymmetric hydrogenation by installing a 2′-hydroxyl substituent is described. This methodology accommodates trisubstituted olefinic substrates in various E/Z mixtures, leading to valuable benzylic chiral compounds including (R)-tolterodine. It is also demonstrated that the 2′-hydroxyl groups could be readily removed in high yield without loss of ee from the products. Thus, this technology represents an attractive alternative to the Ir(P-N) catalyst system for the asymmetric hydrogenation of unfunctionalized olefins.

Method for producing 3,3-diarylpropylamines

The invention relates to a novel method for producing 3,3-diarylpropylamines of formula (I), wherein A represents a substituted or unsubstituted aryl radical, X represents H, OH or OR3 and Y, R1, R2 and R3 have