389130-68-1

Usage

Uses

Used in Pharmaceutical Industry:
2,3-dimethyl-5-benzyloxy-6-carboxy-4-pyrimidinone is used as a potential drug candidate for its pharmacological activities. 2,3-dimethyl-5-benzyloxy-6-carboxy-4-pyrimidinone's unique structure, including the carboxy, benzyloxy, and methyl groups, may contribute to its interaction with biological targets, making it a promising candidate for the development of new therapeutic agents.
Used in Organic Synthesis:
2,3-dimethyl-5-benzyloxy-6-carboxy-4-pyrimidinone is used as a chemical intermediate in the synthesis of more complex organic compounds. Its versatile structure allows for further functionalization and modification, which can be exploited in the preparation of a wide range of chemical products, including pharmaceuticals, agrochemicals, and other specialty chemicals.

Upstream product

• 389130-71-6 ethyl 5-(benzyloxy)-2-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate 
• 90007-74-2 2-methyl-3H-5-hydroxy-6-carboxy-4-pyrimidinone ethyl ester 
• 30379-54-5 benzyloxyacetate de benzyle 
• 389130-64-7 2-methyl-3H-5-tetrahydropyran-2-yloxy-6-tetrahydropyran-2-yloximethyl-4-pyrimidinone 
• 389130-66-9 2,3-dimethyl-5-hydroxy-6-(hydroxymethyl)-4-pyrimidinone hydrochloride 
• 389130-65-8 2,3-dimethyl-5-tetrahydropyran-2-yloxy-6-tetrahydropyran-2-yloxymethyl-4-pyrimidinone 
• 389130-72-7 2,3-dimethyl-5-benzyloxy-6-carboxy-4-pyrimidinone ethyl ester 
• 389130-67-0 2,3-Dimethyl-5-benzyloxy-6-(hydroxymethyl)-4-pyrimidinone 

Downstream Products

• 389130-72-7 2,3-dimethyl-5-benzyloxy-6-carboxy-4-pyrimidinone ethyl ester 
• 1449589-85-8 N-methyl-2,3-dimethyl-5-benzyloxy-6-carboxyamido-4-pyrimidinone 
• 872462-57-2 5-benzyloxy-2,3-dimethyl-6-(4-nitrophenyloxycarbonyl)-1[H]-pyrimidin-4-one 

Relevant academic research and scientific papers

A novel VIVO-pyrimidinone complex: Synthesis, solution speciation and human serum protein binding

The pyrimidinones mhcpe, 2-methyl-3H-5-hydroxy-6-carboxy-4-pyrimidinone ethyl ester (mhcpe, 1), 2,3-dimethyl-5-benzyloxy-6-carboxy-4-pyrimidinone ethyl ester (dbcpe, 2) and N-methyl-2,3-dimethyl-5-hydroxy-6-carboxyamido-4- pyrimidinone (N-MeHOPY, 3), are

2-HYDROXY-1-OXO 1,2 DIHYDRO ISOQUINOLINE CHELATING AGENTS

The invention provides a new class of strongly chelating multidentate ligands based on a 2-hydroxy-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid scaffold (hereafter 1,2-HOIQO) in combination with polyamine backbones. The extremely stable bidentate 1,2- HOIQO moiety can be synthesized by standard synthetic methodology on a large scale. An advantageous feature is the possibility to introduce a wide range of substituents on the benzene ring by standard transformations (like electrophilic aromatic substitutions). This allows, for example, for the tuning of chemical, photophysical, and solubility properties, as well as the attachment of functional moieties, relevant for sensing and imaging applications (e.g. DNA, proteins, antibodies, fluorophores, etc.). The combination of the 1,2-HOIQO chelators with polyamine backbones provides very strongly binding ligands for a variety of metals including first-row transition metals, lanthanides, actinides, etc. Metal complexes of this kind are expected to be useful in a number of applications (e.g. luminescence, MRI, actinide sequestering, metal chelation therapy, metal radioisotope labeling, etc.).

Hydroxypyridonate and hydroxypyrimidinone chelating agents

The present invention provides hydroxypyridinone and hydroxypyrimidone chelating agents. Also provides are Gd(III) complexes of these agents, which are useful as contrast enhancing agents for magnetic resonance imaging. The invention also provides methods of preparing the compounds of the invention, as well as methods of using the compounds in magnetic resonance imaging applications.