389140-35-6

Basic information

• Product Name: Propanedioic acid, (cis-4-carboxycyclohexyl)-, 1,3-diethyl ester
• CAS NO: 389140-35-6
• Molecular Formula: C14H22O6
• Molecular Weight: 286.325
• Mol File: 389140-35-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (cis-4-carboxycyclohexyl)-, 1,3-diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (cis-4-carboxycyclohexyl)-, 1,3-diethyl ester(389140-35-6)
• EPA Substance Registry System: Propanedioic acid, (cis-4-carboxycyclohexyl)-, 1,3-diethyl ester(389140-35-6)

Safety Data

• Hazardous Substances Data: 389140-35-6(Hazardous Substances Data)

Upstream product

• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 3618-04-0 4-hydroxycyclohexyl carboxylic acid ethyl ester 
• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 389140-33-4 p-methoxybenzyl 4-oxo-1-cyclohexanecarboxylate 
• 389140-34-5 p-methoxybenzyl 4-bis-ethoxycarbonylmethylene-1-cyclohexanecarboxylate 

Downstream Products

• 389140-51-6 methyl 6-[(E)-2-[4-{(cis-4-bis-ethoxycarbonylmethyl)cyclohexanecarbonylamino}phenyl]-N-(3-cyclohexylpropyl)ethenylsulfonamido]hexanoate 
• 389140-48-1 methyl 6-[(E)-2-[4-{(cis-4-bis-ethoxycarbonylmethyl)cyclohexanecarbonylamino}phenyl]-N-(5-methylhexyl)ethenylsulfonamido]hexanoate 

Relevant articles and documents

Design and synthesis of non-peptidic inhibitors for the Syk C-terminal SH2 domain based on structure-based in-silico screening

Structure-based in-silico screening was carried out for the Syk C-terminal SH2 domain. Fragments that could interact with the pY or pY+1 pockets were selected by our in-silico screening. After tethering two fragments bound to these pockets, we have designed and synthesized new compounds that show favorable interaction with the pY+3 pocket. One such compound, having a cyclohexylmalonic acid moiety identified as a novel potent phosphotyrosyl mimetic, exhibited an affinity comparable to that of the monophosphorylated ligand peptide.