38916-51-7

Upstream product

• 63024-77-1 3-(Chloromethyl)benzoyl chloride 
• 100-51-6 benzyl alcohol 
• 31719-77-4 3-chloromethylbenzoic acid 

Downstream Products

• 138591-69-2 3-[(Methyl-prop-2-ynyl-amino)-methyl]-benzoic acid benzyl ester 
• 392743-60-1 3-[(diethoxyphosphinyl)methyl]benzoic acid benzyl ester 
• 1352949-17-7 tert-butyl 3-(3-(benzyloxycarbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate 
• 342023-97-6 3-[4-(3-ethoxy-3-oxo-1-propyl)-3-phenyl-1H-pyrazol-1-ylmethyl]benzoic acid 
• 392743-61-2 3-{bis[4-(phenylsulfonyl)phenoxy]phosphinylmethyl}benzoic acid benzyl ester 

Relevant academic research and scientific papers

Reactive immunization elicits catalytic antibodies for polyester hydrolysis

In the search for biocatalysts for degradation of nonnatural polymers, reactive immunization with haptens 7 and 11 was used to prepare catalytic antibodies capable of cleaving short oligomeric esters, as well as the insoluble polyester 25. These antibodies were found to be highly specific and efficient esterases for oligomers. Triester 24 was preferentially hydrolyzed by an endo-cleavage pathway, however, with a higher molecular weight polymer 25 no site specificity could be observed. Catalytic efficiency of the antibodies towards the insoluble polymer 25 was limited due to physical constraints.

Synthesis, biological evaluation and quantitative structure activity relationship analysis of nuclearsubstituted pargylines as competitive inhibitors of MAO-A and MAO-B

A series of nuclear substituted derivatives of pargyline has been prepared and tested (under controlled conditions designed to measure the competitive component of the inhibition) as competitive inhibitors of MAO-A and -B. Adequate correlation of the biological data with the physicochemical constants of substituent groups was obtained only when the m- and p-substituted derivatives were considered separately. Due to the narrow range of activity displayed by the p-substituted derivates when inhibiting MAO-B, meaningful correlations were not found. However, the inhibition of MAO-B by the m-substituted derivatives required the inclusion of the Verloop L parameter for adequate correlation suggesting that the inhibitor binding site of MAO-B is present within a cavity of more limited lateral dimensions than that present on the MAO-A surface. Inhibition of both MAO-A and -B demonstrated a parabolic relationship between inhibitory activity and Π. Whereas this parabolic relationship showed a maximal value for inhibition of MAO-A (mean Π0 = 0.86), inhibition of MAO-B demonstrated a minimal value of Π(Π(min) = -0.5)i.e.the optimal value of Π for inhibition of MAO-B has not been achieved for this series of compounds but such would be greater than that demonstrated for MAO-A. The Hammett σ function was important or significant only in the inhibition of MAO-A by the p-substituted derivatives.