Welcome to LookChem.com Sign In|Join Free

CAS

  • or

38922-77-9

Post Buying Request

38922-77-9 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

38922-77-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 38922-77-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,9,2 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 38922-77:
(7*3)+(6*8)+(5*9)+(4*2)+(3*2)+(2*7)+(1*7)=149
149 % 10 = 9
So 38922-77-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H10N2O2/c1-2-14-10(13)8-7-12-6-4-3-5-9(12)11-8/h3-7H,2H2,1H3

38922-77-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H35384)  Ethyl imidazo[1,2-a]pyridine-2-carboxylate, 95%   

  • 38922-77-9

  • 1g

  • 458.0CNY

  • Detail
  • Alfa Aesar

  • (H35384)  Ethyl imidazo[1,2-a]pyridine-2-carboxylate, 95%   

  • 38922-77-9

  • 10g

  • 2974.0CNY

  • Detail
  • Aldrich

  • (737550)  Ethyl imidazo[1,2-a]pyridine-2-carboxylate  97%

  • 38922-77-9

  • 737550-1G

  • 250.38CNY

  • Detail

38922-77-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl imidazo[1,2-a]pyridine-2-carboxylate

1.2 Other means of identification

Product number -
Other names Imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:38922-77-9 SDS

38922-77-9Relevant articles and documents

DNA binding ligands targeting drug-resistant bacteria: Structure, activity, and pharmacology

Kaizerman, Jacob A.,Gross, Matthew I.,Ge, Yigong,White, Sarah,Hu, Wenhao,Duan, Jian-Xin,Baird, Eldon E.,Johnson, Kirk W.,Tanaka, Richard D.,Moser, Heinz E.,Bürli, Roland W.

, p. 3914 - 3929 (2003)

We describe the lead optimization and structure-activity relationship of DNA minor-groove binding ligands, a novel class of antibacterial molecules. These compounds have been shown to target A/T-rich sites within the bacterial genome and, as a result, inhibit DNA replication and RNA transcription. The optimization was focused on N-terminal aromatic heterocycles and C-terminal amines and resulted in compounds with improved in vivo tolerability and excellent in vitro antibacterial potency (MIC ≥ 0.031 μg/mL) against a broad range of Gram-positive pathogens, including drug-resistant strains such as methicillin-resistant Stapylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), and vancomycin-resistant Enterococcus faecalis (VRE). In a first proof-of-concept study, a selected compound (35) showed in vivo efficacy in a mouse peritonitis model against methicillin-sensitive S. aureus infection with an ED50 value of 30 mg/kg.

Synthesis and biological evaluation of novel imidazo[1,2-a]pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding

Babu, Bathini Nagendra,Jadhav, Govinda Shivaji,Kadagathur, Manasa,Kiranmai, Gaddam,Nagesh, Narayana,Parimala Devi, G.,Sana, Sravani,Shankaraiah, Nagula,Sigalapalli, Dilep Kumar,Tangellamudi, Neelima D.,Tokala, Ramya,Tripura, Chaturvedula

, (2021/06/30)

Efforts towards the development of potential anticancer agents, a new series of imidazo[1,2-a]pyridine-oxadiazole hybrids were synthesized and evaluated for their in vitro anticancer activity against lung cancer (A549) and prostate cancer (PC-3, DU-145) cell lines. Amongst the compounds tested, 6d showed the highest potency on A549 cells with an IC50 value of 2.8 ± 0.02 μM. Flow cytometric analysis of compound 6d treated A549 cells showed apoptosis induction by annexin-v/PI dual staining assay and the effect of 6d on different phases of cell cycle was also analyzed. Target based studies demonstrated the inhibition of tubulin polymerization by 6d at an IC50 value of 3.45 ± 0.51 μM and its effective binding with CT-DNA. Further, the molecular modelling studies revealed that 6d has a prominent binding affinity towards α/β-tubulin receptor with admirable physico-chemical properties.

Design, synthesis, in vitro evaluation and molecular docking study of N'-Arylidene imidazo [1,2-a] pyridine -2-carbohydrazide derivatives as novel Tyrosinase inhibitors

Damghani, Tahereh,Edraki, Najmeh,Hadaegh, Saba,Khoshneviszadeh, Mehdi,Pirhadi, Somayeh,Sabet, Razieh,khoshneviszadeh, Mahsima

, (2020/07/21)

A novel series of imidazo[1,2-a]pyridine 2-carbohudrazide derivatives bearing different arylidene pendantrs were designed, synthesized and evaluated for their inhibitory activity against mushroom Tyrosinase. It was found that compounds bearing 3-nitro (6j) and 4?hydroxy (6g) moieties on the arylidene pendant exhibited the best Tyrosinase inhibitory activity with IC50 values of 7.19 and 8.11 μM, respectively. These results were comparable to that of kojic acid as the reference drug (IC50 = 9.64±0.5 μM). Additionally, molecular docking analysis was performed to study the interactions and binding modes of compounds 6j, 6h and 6g which are showing the potential of two critical pi-pi interactions with His263 and Phe264 in the active site of Tyrosinase. The results indicated that 6j and 6g could be introduced as potent Tyrosinase inhibitors that might serve as promising candidates in medicine, cosmetics or food industry.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 38922-77-9