38927-34-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-deoxypentofuranosyl)-5-thiocyanatopyrimidine-2,4(1H,3H)-dione is used as a potential therapeutic agent for targeting specific diseases. The addition of a thiocyanate group to the pyrimidine ring may provide it with unique biochemical properties that could be exploited in the development of antiviral and anticancer drugs.
Further research is necessary to fully understand the compound's potential uses and effects in medicine, as well as to optimize its delivery and bioavailability for improved therapeutic outcomes.

Upstream product

• 951-78-0 2'-deoxyuridine 
• 592-87-0 lead(II) thiocyanate 

Downstream Products

• 145531-59-5 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-thiocyanato-1H-pyrimidine-2,4-dione 
• 7085-54-3 1-(2-Deoxy-β-D-ribofuranosyl)-5-mercaptouracil 
• 145531-61-9 Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-5-thiocyanato-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 

Relevant academic research and scientific papers

Synthesis and Utility of 5-Thiocyanato Deoxyuridine and Uridine Phosphoramidites as Masked Synthons

5-Thiocyanato-2'-deoxyuridine and 5-thiocyanato-uridine phosphoramidites have been synthesized and incorporated into DNA and RNA trimers via automated methodology.The SCN group has been removed with DTT treatment, and a photocrosslinking aryl azide has be

Synthesis, chemistry, and biological activity of 5 thiocyanatopyrimidine nucleosides as potential masked thiols

The reaction of chlorothiocyanogen (ClSCN) with various derivatives of uracil was investigated as potential route to 5 mercaptouracils. Reaction of 1,3 dimethyluracil, 1 (β D ribofuranosyl)uracil, 1 (2' deoxy β D ribofuranosyl)uracil, 1 (β D arabinofuranosyl)uracil, 1 (2',3',5' tri O chloroacetyl β D ribofuranosyl)uracil, and 1 (2',3',5' tri O acetyl β D ribofuranosyl)uracil with ClSCN in acetic acid gave the corresponding 5 thiocyanato derivatives in fair to excellent yields. These 5 thiocyanatopyrimidine nucleosides can be reduced by dithiothreitol, sodium dithionite 2 mercaptoethanol, or glutathione to the biologically active 5 mercaptopyrimidine nucleosides. The intermediate 5 thiocyanatopyrimidine nucleosides show significant biological activity, probably as the result of in vivo reduction.