38947-57-8

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Diphenylisonicotinic acid is used as a reactant for the synthesis of 7-substituted spiro[chroman-2,4′-piperidin]-4-one derivatives. These derivatives have potential applications in the development of new pharmaceutical compounds, particularly in the treatment of various medical conditions.
Used in Chemical Synthesis:
2,6-Diphenylisonicotinic acid is also used as a reactant in the synthesis of ethyl 2,6-diphenylisonicotinate, which is a tridentate ligand. Tridentate ligands are important in coordination chemistry and can be used to form complexes with metal ions, leading to the development of new materials and catalysts.

InChI:InChI=1/C18H13NO2/c20-18(21)15-11-16(13-7-3-1-4-8-13)19-17(12-15)14-9-5-2-6-10-14/h1-12H,(H,20,21)

Upstream product

• 17812-07-6 Benzoylacrylic acid 
• 16883-69-5 N-phenacylpyridinium bromide 
• 77953-17-4 4-oxo-2-phenacyl-4-phenyl-butyric acid 
• 102078-89-7 4-ethoxycarbonyl-2,6-diphenylpyridine 

Downstream Products

• 103158-05-0 2,6-diphenyl-isonicotinic acid-(5-diethylamino-pentylamide) 
• 112116-62-8 2,6-diphenyl-isonicotinic acid-(3-dimethylamino-propylamide) 
• 123188-19-2 2,6-diphenyl-isonicotinic acid-(2-diethylamino-ethyl ester); hydrochloride 
• 121655-63-8 2,6-diphenyl-isonicotinic acid-(3-dipropylamino-propylester); hydrochloride 
• 1258211-72-1 Ga₂(CH(SiMe₃)2)2(2,6-diphenylisonicotinate)2 
• 102078-89-7 4-ethoxycarbonyl-2,6-diphenylpyridine 
• 1401341-28-3 C₆₃H₇₅NO₈Rh₂ 
• 1401341-29-4 C₆₆H₆₆N₂O₈Rh₂ 
• 1430330-67-8 N-(1,1-dioxo-1H-1λ⁶-benzo[b]thiophen-6-yl)-2,6-diphenyl-isonicotinamide 
• 1131680-08-4 C₃₃H₃₀N₂O₃ 
• 1131680-06-2 C₃₇H₃₃N₃O₄ 
• 1131680-02-8 C₃₇H₃₇N₃O₄ 
• 1131680-00-6 C₃₅H₃₃N₃O₃ 

Relevant academic research and scientific papers

2,6-diphenylpyridine-4-carboxylic acid

The crystal structure of 2,6-diphenylpyridine-4-carboxylic acid, C18H13NO2 was studied. Dihedral angles between the plane of pyridine and those of the phenyl substituents were found to be 8.7 and 9.8 (1)°. The shortest int

Studies with β-oxoalkanonitriles: Simple novel synthesis of 3-[2,6-diaryl-4- pyridyl]-3-oxopropanenitriles

Heteroaromatization of ethyl 2-cyano-4-oxo-2-(2-oxo-2-arylethyl)-4- arylbutanoates 3a,b with ammonium acetate gave ethyl 2,6-diarylisonicotinates 4a,b. Treatment of the latter with acetonitrile afforded novel β-oxoalkanonitriles 6a,b. Reactions of 6a,b wi

Replacement of the quinoline system in 2-phenyl-4-quinolinecarboxamide NK-3 receptor antagonists

Results from a medicinal chemistry approach aimed at replacing the quinoline ring system in the potent and selective human neurokinin-3 (hNK-3) receptor antagonists 1-4 of general formula I are discussed. The data give further insight upon the potential NK-3 pharmacophore. In particular, it is highlighted that both the benzene-condensed ring and the quinoline nitrogen are crucial determinants for optimal binding affinity to the hNK-3 receptor. Some novel compounds maintained part of the binding affinity to the receptor (5, 6, 10 and 13) and compound 5, featuring the naphthalene ring system, appears to be suitable for further modifications: it offers the option to introduce electron-withdrawing groups at position 2 and 4, conferring on the ring an overall electron-deficiency similar to that of the quinoline.