389571-69-1Relevant articles and documents
METHOD FOR PRODUCING ANILINE COMPOUND
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Paragraph 0037, (2020/03/28)
PROBLEM TO BE SOLVED: To provide a method for highly selectively producing 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline from 3-bromo-5-trifluoromethylaniline. SOLUTION: There is provided a method for producing 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, which comprises (1) a step of obtaining 3-iodo-5-trifluoromethylaniline by reacting 3-bromo-5-trifluoromethylaniline and an iodizing agent in a solvent in the presence of a transition metal catalyst and a compound represented by the formula [6] (wherein, R1 and R2 are the same or different and represents an alkyl group, W represents a divalent hydrocarbon group) and (2) a step of obtaining 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline by reacting the 3-iodo-5-trifluoromethylaniline obtained in the step (1) and 4-methyl-1H-imidazole in the presence of a base. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT