389602-55-5

Downstream Products

• 486435-00-1 N-[4-(3-methyl-5-phenyl-pyrazol-1-yl)-phenylmethyl]-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-pyrrole-2-carboxylic acid amide 
• 486434-51-9 N-[4-(3-methyl-5-phenyl-pyrazol-1-yl)-phenylmethyl]-2-(biphenyl-2-carbonylamino)-thiazole-4-carboxylic acid amide 
• 486434-68-8 N-[4-(3-methyl-5-phenyl-pyrazol-1-yl)-phenylmethyl]-5-(4'-trifluoromethylbiphenyl-2-carbonylamino)-nicotinic acid amide 
• 389601-06-3 N-[4-(3-methyl-5-phenyl-pyrazol-1-yl)-phenylmethyl]-3-(4'-fluorobiphenyl-2-carbonylamino)-benzoic acid amide 
• 389601-05-2 N-[4-(3-methyl-5-phenyl-pyrazol-1-yl)-phenylmethyl]-3-(biphenyl-2-carbonylamino)-benzoic acid amide 
• 389601-04-1 N-[4-(3-methyl-5-phenyl-pyrazol-1-yl)-phenylmethyl]-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide 
• 389601-03-0 N-[4-(3-methyl-5-phenyl-pyrazol-1-yl)-phenylmethyl]-3-(4'-methylbiphenyl-2-carbonylamino)-benzoic acid amide 

Relevant academic research and scientific papers

Combination of MTP inhibitors or apoB-secretion inhibitors with fibrates for use as pharmaceuticals

The invention relates to the use of fibrates for lowering the liver toxicity of MTP inhibitors as well as pharmaceutical compositions containing an MTP inhibitor and a fibrate.

Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments

The present invention relates to substituted piperazine derivatives of general formula wherein R1 to R7 are defined herein, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.