389615-05-8

Basic information

• Product Name: 1H-Pyrrole-2-carboxylicacid,4-amino-3-methoxy-1-methyl-,ethylester(9CI)
• Synonyms: 1H-Pyrrole-2-carboxylicacid,4-amino-3-methoxy-1-methyl-,ethylester(9CI)
• CAS NO: 389615-05-8
• Molecular Formula: C9H14N2O3
• Molecular Weight: 0
• Product Categories: AMINOACID
• Mol File: 389615-05-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-2-carboxylicacid,4-amino-3-methoxy-1-methyl-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxylicacid,4-amino-3-methoxy-1-methyl-,ethylester(9CI)(389615-05-8)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxylicacid,4-amino-3-methoxy-1-methyl-,ethylester(9CI)(389615-05-8)

Safety Data

• Hazardous Substances Data: 389615-05-8(Hazardous Substances Data)

Upstream product

• 389615-04-7 3-methoxy-1-methyl-4-nitro-1H-pyrrole-2-carboxylic ethyl ester 

Relevant articles and documents

Process for the preparation of derivative of 4-amino-3-hydroxypyrrole-2-carboxylic acid

Novel processes and intermediates are provided for the synthesis of derivatives of 4-amino-3-hydroxypyrrole-2-carboxylic acids that are useful as monomers for polyamides capable of binding dsDNA. According to one preferred reaction scheme, an alkyl alkoxymethylene nitroacetate (Formula VIII) is prepared by reaction of a trialkyl orthoformate or orthoacetate with a nitroacetate ester in the presence of a carboxylic anhydride. The compound of Formula VIII is condensed with an N-substituted glycine to yield an N-substituted (2-nitro-2-alkoxycarbonyl)vinyl glycinate ester (Formula VII). Ring closure in the presence of an alkali metal alkoxide yields a 4-nitro-3-hydroxypyrrole-2-carboxylic ester (Formula V). After blocking of the 3-hydroxy group to produce a further intermediate (Formula IV), the 4-nitro group is reduced to a 4-amino group (Formula III), and the 4-amino group is then blocked by reaction with a dicarbonate diester to produce the fully blocked intermediate (Formula II). Saponification of the 2-carboxylic acid ester yields a monomer having a free 2-carboxylic ester moiety (Formula I).