389621-81-2

Basic information

• Product Name: 4-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID
• Synonyms: 4-(1-PYRROLIDINYLCARBONYL)PHENYLBORONIC ACID;4-PYRROLIDINYLCARBONYLPHENYLBORONIC ACID;4-(PYRROLIDINE-1-CARBONYL)BENZENEBORONIC ACID;4-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID;N-PYRROLIDINYL 4-BORONOBENZAMIDE;Boronic acid, [4-(1-pyrrolidinylcarbonyl)phenyl]- (9CI);(4-boronophenyl)(pyrrolidin-1-yl)methanone;1-(4-Boronobenzoyl)pyrrolidine
• CAS NO: 389621-81-2
• Molecular Formula: C₁₁H₁₄BNO₃
• Molecular Weight: 219.04
• Product Categories: BORONICACID;blocks;BoronicAcids;Boronic acids;Aryl;Organoborons;Boronate Ester;Boronic Acid;Potassium Trifluoroborate
• Mol File: 389621-81-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 136-140°C
• Boiling Point: 446.949 °C at 760 mmHg
• Flash Point: 224.107 °C
• Appearance: /
• Density: 1.26
• Vapor Pressure: 9E-09mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 8.18±0.16(Predicted)
• CAS DataBase Reference: 4-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID(389621-81-2)
• EPA Substance Registry System: 4-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID(389621-81-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 389621-81-2(Hazardous Substances Data)

Usage

General Description

4-(Pyrrolidine-1-carbonyl)phenylboronic Acid is a specialized chemical compound that has applications in various scientific and industrial areas. It is primarily characterized by the presence of a boronic Acid functional group in combination with a phenyl group (an aromatic ring), and a pyrrolidine group, a compound that contains a five-membered ring. 4-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID is typically used in chemical synthesis where its boronic acid functionality often enables selective reactions. It is commonly used in the field of medicinal chemistry and organic synthesis, specifically in the Suzuki-Miyaura cross-coupling reactions for creating carbon-carbon bonds. However, its exact properties such as toxicity, flammability or environmental hazards may vary depending on its specific chemical structure and it should be handled according to safety data sheets provided by the manufacturer.

InChI:InChI=1/C11H14BNO3/c14-11(13-7-1-2-8-13)9-3-5-10(6-4-9)12(15)16/h3-6,15-16H,1-2,7-8H2

Upstream product

• 56302-41-1 4-carboxamidopyrrolidinophenyl-aniline 
• 13675-18-8 tetrahydroxydiboron 

Downstream Products

• 940956-33-2 4'-(pyrrolidine-1-carbonyl)-biphenyl-3-carboxylic acid [5-(3-ethoxy-5-trifluoromethyl-pyrazol-1-yl)-pyridin-2-yl]-amide 
• 1620483-71-7 C₂₇H₂₆FN₃O₃ 
• 1403396-14-4 8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-{1-[4'-(pyrrolidin-1-ylcarbonyl)biphenyl-4-yl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1384958-46-6 ethyl 2-amino-3-methyl-7-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxylate 
• 1384958-48-8 ethyl 2-amino-7-[4-(pyrrolidin-1-ylcarbonyl)phenyl]spiro[1-benzazepine-3-cyclopropane]-4-carboxylate 
• 1384958-47-7 ethyl 2-amino-3,3-dimethyl-7-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxylate 
• 1384958-42-2 (E)-ethyl 9-(4-(pyrrolidine-1-carbonyl)phenyl)-2,4-dihydro-1H-benzo[f]imidazo[1,2-a]azepine-5-carboxylate 
• 1384958-36-4 (1E,4E)-ethyl 2-amino-7-methoxy-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylate 
• 1384958-34-2 (1E,4E)-ethyl 2-amino-7-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylate 
• 1384958-71-7 (1E,4E)-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-(2-(dimethylamino)ethylamino)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide 
• 1384958-41-1 (1E,4E)-2-(2-(dimethylamino)ethylamino)-N-(3-hydroxypropyl)-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide 
• 1384958-70-6 ethyl 1-cyanocyclopropyl((3-nitro-4'-(pyrrolidine-1-carbonyl)biphenyl-4-yl)methyl)carbamate 

Relevant articles and documents

Sequential one-pot access to molecular diversity through aniline aqueous borylation

On the basis of our recently reported aniline aqueous borylation, molecular diversity was achieved in a one-pot process by combining other reactions such as esterification, Suzuki-Miyaura coupling, hydrogenolysis, or Petasis borono-Mannich.