38965-77-4

Usage

Uses

Used in Pharmaceutical Applications:
trans-1-(2-Hydroxy-4-methoxy-3-(3-methyl-2-butenyl)phenyl)-3-phenyl-2-propen-1-one is used as an anticancer agent for its ability to suppress human colon cancer cell growth. It achieves this by inhibiting the Wnt/β-catenin signaling pathway, which plays a crucial role in the development and progression of various cancers.
Used in Developmental Biology Research:
In the field of developmental biology, trans-1-(2-Hydroxy-4-methoxy-3-(3-methyl-2-butenyl)phenyl)-3-phenyl-2-propen-1-one is used to inhibit double axis formation in Xenopus laevis embryos. This property makes it a valuable tool for studying the underlying mechanisms of embryonic development and the role of Wnt/β-catenin signaling in this process.
Used in Chemical Synthesis:
Due to its unique structure, trans-1-(2-Hydroxy-4-methoxy-3-(3-methyl-2-butenyl)phenyl)-3-phenyl-2-propen-1-one may also be used as a starting material or intermediate in the synthesis of other complex organic compounds, potentially leading to the development of new pharmaceuticals or chemical products with various applications.

InChI:InChI=1/C21H22O3/c1-15(2)9-11-18-20(24-3)14-12-17(21(18)23)19(22)13-10-16-7-5-4-6-8-16/h4-10,12-14,23H,11H2,1-3H3/b13-10+

Upstream product

• 128961-25-1 1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one 
• 52601-05-5 Isocordoin 
• 74-88-4 methyl iodide 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 

Downstream Products

• 124439-13-0 2,3-dihydro-8-(3-hydroxy-3-methylbut-1-enyl)-7-methoxy-2-phenyl-4H-1-benzopyran-4-one 
• 124355-22-2 2,3-dihydro-8-(2,3-epoxy-3-methylbutyl)-7-methoxy-2-phenyl-4H-1-benzopyran-4-one 
• 124355-21-1 2,3-dihydro-7-methoxy-8-(3-methylbut-2-enyl)-2-phenyl-4H-1-benzopyran-4-one 

Relevant academic research and scientific papers

Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin

An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 μg/mL and 75 μg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.

Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei

Chalcones bearing prenyl or geranyl groups from Angelica keiskei, such as 4-hydroxyderricin (1a), xanthoangelol (1e), xanthoangelol F (1f), xanthoangelol H (2), deoxyxanthoangelol H (3), and deoxydihydroxanthoangelol H (4) and their derivatives were synthesized. From the evaluation of antibacterial activity of the synthesized chalcones, 1a, isobavachalcone (1b), 1e, 1f, bavachalcone (5a), and broussochalcone B (5b) were found to inhibit Gram-positive bacteria.