Gelsemine, 1-methoxy-, also known as Gelsevirine, is a derivative of Gelsemine (G304560), which is the principal alkaloid found in the yellow jasmine (Gelsemium) plant. Gelsemine, 1-methoxyhas been recognized for its ability to activate spinal α3 glycine receptors, leading to antinociception (pain relief). Additionally, Gelsemine possesses anxiolytic properties, making it a potential candidate for various therapeutic applications.
38990-03-3
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Basic information
- Product Name: Gelsemine, 1-methoxy-
- Synonyms: Gelsemine, 1-methoxy-;1-Methoxygelsemine
- CAS NO:38990-03-3
- Molecular Formula: C21H24N2O3
- Molecular Weight: 352.43
- EINECS: N/A
- Product Categories: Alkaloids
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 456.6°Cat760mmHg
- Flash Point: 229.9°C
- Appearance: /
- Density: 1.34g/cm3
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 8.85±0.40(Predicted)
- CAS DataBase Reference: Gelsemine, 1-methoxy-(CAS DataBase Reference)
- NIST Chemistry Reference: Gelsemine, 1-methoxy-(38990-03-3)
- EPA Substance Registry System: Gelsemine, 1-methoxy-(38990-03-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 38990-03-3(Hazardous Substances Data)
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38990-03-3 Usage
Uses
Used in Pharmaceutical Industry:Gelsemine, 1-methoxy-, is used as a therapeutic agent for its antinociceptive properties, providing pain relief through the activation of spinal α3 glycine receptors. This application is particularly relevant for the development of treatments for chronic pain conditions.
Gelsemine, 1-methoxy-, is also used as an anxiolytic agent due to its ability to alleviate anxiety. This makes it a potential candidate for the development of treatments for anxiety disorders and other related conditions.
Used in Neurological Applications:
In the field of neurology, Gelsemine, 1-methoxy-, is used as a research tool to study the function and role of spinal α3 glycine receptors in pain transmission and modulation. Understanding the mechanisms of action of Gelsemine, 1-methoxy- can contribute to the development of novel therapeutic strategies for pain management and anxiety treatment.
Used in Drug Development:
Gelsemine, 1-methoxy-, is used as a lead compound in the development of new drugs targeting spinal α3 glycine receptors for pain relief and anxiety treatment. Its unique properties and mechanisms of action make it a valuable starting point for the design and synthesis of novel therapeutic agents with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 38990-03-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,9,9 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.Calculate Digit Verification of CAS Registry Number 38990-03:
(7*3)+(6*8)+(5*9)+(4*9)+(3*0)+(2*0)+(1*3)=153
153 % 10 = 3
So 38990-03-3 is a valid CAS Registry Number.
38990-03-3Upstream product
38990-03-3Downstream Products
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Gelsemine, 1-methoxy-
