3902-88-3Relevant academic research and scientific papers
Synthesis and biological activity of novel series of 1,3-benzoxazol-2(3H)- one derivatives
Krawiecka, Mariola,Kuran, Bozena,Kossakowski, Jerzy,Kierzkowska, Marta,Mlynarczyk, Grazyna,Cieslak, Marcin,Kazmierczakbaranska, Julia,Krolewska, Karolina,Dobrowolski, Michal A.
, p. 245 - 253 (2013/06/05)
In the search for novel biological agents, a series of new derivatives N-substituted 1,3-benzoxazol-2(3H)-one, 5-chloro-1,3-benzoxazol-2(3H)-one, 6-bromo-1,3-benzoxazol-2(3H)-one were prepared. All of the compounds were characterized by 1H NMR, 13C NMR and ESI MS spectra. Moreover, for compound 1 an Xray structure was determined. All derivatives were tested for antimicrobial activity against a selection of Grampositive, Gram-negative bacteria and yeasts. The selected compounds (2-8, 10) were tested for their cytotoxic properties in K562, HeLa and normal cells.
