39053-47-9

Usage

Uses

Used in Organic Synthesis:
2,4-dimethyl-3-nitrobenzoic acid is used as a starting material for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the creation of a wide range of compounds with different properties and applications.
Used in Pharmaceutical Research:
In the field of pharmaceutical research, 2,4-dimethyl-3-nitrobenzoic acid is utilized as a precursor for the development of new drugs. Its potential anti-inflammatory and analgesic properties make it a valuable compound for the exploration of novel therapeutic agents.
Used in Environmental Science:
2,4-dimethyl-3-nitrobenzoic acid is used as a reagent for the determination of nitrifying bacteria in environmental samples. This application aids in understanding the presence and activity of these bacteria, which play a crucial role in the nitrogen cycle and overall ecosystem health.

Upstream product

• 611-01-8 2,4-dimethyl-benzoic acid 
• 13621-24-4 1-(2,4-dimethyl-3-nitro-phenyl)-ethanone 
• 89-74-7 2,4-dimethylacetophenone. 

Downstream Products

• 39182-95-1 3-amino-2,4-dimethyl-benzophenone 
• 39182-82-6 2,4-dimethyl-3-nitro-benzophenone 
• 87-62-7 2,6-dimethylaniline 
• 81-20-9 2,6-dimethylnitrobenzene 
• 39182-80-4 2,4-dimethyl-3-nitro-benzoyl chloride 
• 64289-45-8 3-amino-2,4-dimethylbenzoic acid 

Relevant academic research and scientific papers

Synthesis and reactivity with β-lactamases of 'penicillin-like' cyclic depsipeptides

Several 7-carboxy-3-amido-3,4-dihydro-2H-1-benzopyran-2-ones have been synthesized as potential β-lactamase substrates and/or mechanism-based inhibitors. Substituted o-tyrosine precursors were prepared by the Sorensen method and then heated in vacuo to give the lactones. These compounds are cyclic analogues of aryl phenaceturates which are known to be β-lactamase substrates. The goal of incorporating the scissile ester group into a lactone was to retain the leaving group tethered to the acyl moiety at the acyl- enzyme stage of turnover by serine β-lactamases, in a manner similar to that during penicillin turnover. Further, in two cases, a functionalized methylene group para to the leaving group phenoxide oxygen was incorporated. These molecules possess a latent p-quinone methide electrophile which could, in principle, be unmasked during enzymic turnover and react with an active site nucleophile. All of these compounds were found to be substrates of class A and C β-lactamases, the first δ-lactones with such activity. Generally, k(cat) values were smaller than for the analogous acyclic depsipeptides, which suggests that the tethered leaving group may obstruct the attack of water on the acyl-enzymes. Further exploration of this structural theme might lead to quite inert acyl-enzymes and thus to significant inhibitors. Despite the apparent advantage offered by the longer-lived acyl-enzymes, the functionalized compounds were no better as irreversible inhibitors than comparable acyclic compounds [Cabaret, D.; Liu, J.; Wakselman, M.; Pratt, R. F.; Xu, Y. Bioorg. Med. Chem. 1994, 2, 757-771]. Thus, even tethered quinone methides, at least when placed as dictated by the structures of the present compounds, were unable to efficiently trap a nucleophile at serine β- lactamase active sites.

Process for the production of nitro derivatives of aromatic compounds

Nitroderivates of aromatic compounds which are difficult to nitrate, can readily be obtained by nitration providing that the aromatic compound is treated with nitric acid or another nitrating agent in the presence of aliphatic or cycloaliphatic hydrocarbons monosubstituted or polysubstituted by halogen, the nitro group or an alkyl sulphonyl group, and the nitro derivative formed subsequently isolated.