39062-73-2Relevant academic research and scientific papers
Synthesis and comparative molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives
Cho, Won-Jea,Kim, Eui-Ki,Park, Myun-Ji,Choi, Sang-Un,Lee, Chong-Ock,Cheon, Seung Hoon,Choi, Bo-Gil,Chung, Byung-Ho
, p. 2449 - 2458 (2007/10/03)
In this study a series of 3-arylisoquinoline derivatives were synthesized and cytotoxicity against human melanoma tumor cell evaluated, and a three dimensional quantitative structure-activity relationship was investigated using the comparative molecular field analysis (CoMFA). The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinolines were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.721) was obtained through CoMFA. Copyright (C) 1998 Elsevier Science Ltd.
Synthesis and biological evaluation of 3-arylisoquinolines as antitumor agents
Cho, Won-Jea,Park, Myun-Ji,Chung, Byung-Ho,Lee, Chong-Ok
, p. 41 - 46 (2007/10/03)
To investigate the structure-activity relationship of 7,8-dimethoxy-2-methyl-3-(4,5-methylenedioxy-2-vinylphenyl)isoquinolin-1(2H) -one 2, diverse substituted 3-arylisoquinolines were synthesized and tested in vitro antitumor activity against five human tumor cell lines. The results showed a broad antitumor spectrum for a series of 3-arylisoquinolines.
