39064-93-2

Basic information

• Product Name: Phenol, 4-[4-(1,1-dimethylethyl)phenoxy]-
• CAS NO: 39064-93-2
• Molecular Formula: C16H18O2
• Molecular Weight: 242.318
• Mol File: 39064-93-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phenol, 4-[4-(1,1-dimethylethyl)phenoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-[4-(1,1-dimethylethyl)phenoxy]-(39064-93-2)
• EPA Substance Registry System: Phenol, 4-[4-(1,1-dimethylethyl)phenoxy]-(39064-93-2)

Safety Data

• Hazardous Substances Data: 39064-93-2(Hazardous Substances Data)

Upstream product

• 98-54-4 para-tert-butylphenol 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 70945-85-6 1-(4-(4-(tert-butyl)phenoxy)phenyl)ethan-1-one 
• 459-57-4 4-fluorobenzaldehyde 
• 108934-20-9 4-(4-tert-butylphenoxy)benzaldehyde 

Downstream Products

• 51338-19-3 2-[4-(4-tert-Butyl-phenoxy)-phenoxy]-propionic acid 
• 151510-40-6 6-(4-tert-Butyl-phenoxy)-2H-chromene-3-carbaldehyde 
• 606966-64-7 (3-{3-[4-(4-tert-butyl-phenoxy)-2-propyl-phenoxy]-propoxy}-phenyl)-hydroxy-acetic acid methyl ester 
• 606966-82-9 4-(4-tert-butyl-phenoxy)-2-propyl-phenol 
• 606966-77-2 C₁₉H₂₂O₂ 
• 831-82-3 4-Phenoxyphenol 
• 151510-37-1 5-(4-tert-Butyl-phenoxy)-2-hydroxy-benzaldehyde 

Relevant articles and documents

Method for selectively preparing hydroquinone monoether compound or quinol compound (by machine translation)

The method comprises the following steps: taking an organic boric acid compound and a p-benzoquinone compound as a reaction raw material, under the action of a copper catalyst, selectively reacting to obtain a hydroquinone monoether compound or a quinol compound. Compared with the prior art, the method disclosed by the invention adopts a one-pot reaction, can selectively obtain two products through solvent control, is suitable for preparing various types of hydroquinone monoether compounds and quinol compounds, and has wide applicability. The substrate functional group is high in tolerance and wide in substrate range. The raw material and the catalyst are cheap and easily available, the reaction conditions are mild, the reaction solvent is green and environment-friendly, the post-treatment is simple, and the yield and purity of the product are high. The preparation method is convenient. The method is rapid and efficient, and has a good application prospect in drug molecule synthesis. (by machine translation)

SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.

A convenient method for the preparation of 4-aryloxyphenols

A convenient method for the preparation of 4-aryloxyphenols via the homologation of preformed phenols is described. Condensation of various 4-substituted phenols with either 4-fluorobenzaldehyde (8) or 4-fluoroacetophenone (9) yielded the corresponding 4-aryl-oxybenzaldehydes, 10, and acetophenones, 11, in 70-93% yield. Baeyer-Villiger oxidation of these materials with 3-chloroperoxybenzoic acid (MCPBA) yielded the corresponding 4-formyloxy and 4-acetoxyphenyl ethers which were hydrolyzed without purification to the desired 4-aryloxyphenols 12 in 72-94% yield. Both 4-fluorobenzaldehyde (8) and 4-fluoroacetophenone (9) are synthetically equivalent to the a4 umpoled synthon 6. Extension of this methodology of the preparation of 4,4'-[arylbis(oxy)]bisphenols from aromatic diols is also described. Condensation of various aromatic diols with 8 or 9 yielded the corresponding 4,4'-[arylbis(oxy)]bisbenzaldehydes 15 and acetophenones 16 in 71-89% yield. Baeyer-Villiger oxidation of these compounds with MCPBA yielded the desired 4,4'-[arylbis(oxy)]bisphenyl bisformates 17 and bisacetates 18 in 67-84% yield. Hydrolysis of these compounds afforded the desired 4,4'-[arylbis(oxy)bisphenols 19 in 70-91% yield.