39075-26-8

Upstream product

• 106-94-5 propyl bromide 
• 134-96-3 syringic aldehyde 
• 107-08-4 1-iodo-propane 

Downstream Products

• 501700-11-4 2-(3,5-Dimethoxy-4-propoxyphenyl)-1-methylethylamin 
• 1351593-47-9 4-(3,5-dimethoxy-4-propoxybenzoyl)-7-ethoxyisoquinolin-8-yl acetate 
• 1351593-93-5 (3,5-dimethoxy-4-propoxyphenyl)(7-ethoxy-8-mercaptoisoquinolin-4-yl)methanone 
• 1351593-91-3 S-(4-(3,5-dimethoxy-4-propoxybenzoyl)-7-ethoxyisoquinolin-8-yl) dimethylcarbamothioate 
• 1351593-56-0 O-(4-(3,5-dimethoxy-4-propoxybenzyl)-7-ethoxyisoquinolin-8-yl) dimethylcarbamothioate 
• 1351593-54-8 (3,5-dimethoxy-4-propoxyphenyl)(7-ethoxy-8-hydroxyisoquinolin-4-yl)methanone 
• 1351593-53-7 (8-(benzyloxy)-7-ethoxyisoquinolin-4-yl)(3,5-dimethoxy-4-propoxyphenyl)methanone 
• 1351593-52-6 8-(benzyloxy)-4-(3,5-dimethoxy-4-propoxybenzyl)-7-ethoxyisoquinoline 
• 1351593-50-4 (8-amino-7-ethoxyisoquinolin-4-yl)(3,5-dimethoxy-4-propoxyphenyl)methanone 
• 1351593-48-0 4-(3,5-dimethoxy-4-propoxybenzyl)-7-ethoxyisoquinolin-8-yl acetate 
• 1351593-46-8 4-(3,5-dimethoxy-4-propoxybenzyl)-7-ethoxyisoquinolin-8-amine 
• 1351593-45-7 4-(3,5-dimethoxy-4-propoxybenzyl)-N-(diphenylmethylene)-7-ethoxyisoquinolin-8-amine 
• 1351593-44-6 4-(3,5-dimethoxy-4-propoxybenzyl)-7-ethoxyisoquinolin-8-yl trifluoromethanesulfonate 
• 1351592-44-3 4-(3,5-dimethoxy-4-propoxybenzyl)-7-ethoxyisoquinolin-8-ol 

Relevant academic research and scientific papers

Synthesis, antiepileptic effects, and structure-activity relationships of α-asarone derivatives: In vitro and in vivo neuroprotective effect of selected derivatives

In the present study, we compared the antiepileptic effects of α-asarone derivatives to explore their structure-activity relationships using the PTZ-induced seizure model. Our research revealed that electron-donating methoxy groups in the 3,4,5-position on phenyl ring increased antiepileptic potency but the placement of other groups at different positions decreased activity. Besides, in allyl moiety, the optimal activity was reached with either an allyl or a 1-butenyl group in conjugation with the benzene ring. The compounds 5 and 19 exerted better neuroprotective effects against epilepsy in vitro (cell) and in vivo (mouse) models. This study provides valuable data for further exploration and application of these compounds as potential anti-seizure medicines.

SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS

The present invention relates generally to substituted isoquinolines and their use as tubulin polymerization inhibitors. In particular, the invention relates to substituted isoquinolines which possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds

Synthesis of novel (phenylalkyl)amines for the investigation of structure-activity relationships. Part 1. Mescalin derivatives

The synthesis and the spectroscopic data of 14 novel 4-substituted mescaline derivatives are reported. Starting from syringaldehyde (=4-hydroxy-3,5-dimethoxybenzaldehyde), several ethers were obtained from reaction with a series of corresponding saturated and unsaturated alkyl- and fluoroalkyl halides. Henry-reaction with MeNO2 or EtNO2 followed to afford the nitro-olefines, which were then reduced with AlH3 to the desired 2-phenytethyl- and 1-methyl-2-phenylethylamine derivatives.