390800-88-1 Usage
Uses
Bortezomib Trimer is derived from Bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
Check Digit Verification of cas no
The CAS Registry Mumber 390800-88-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,0,8,0 and 0 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 390800-88:
(8*3)+(7*9)+(6*0)+(5*8)+(4*0)+(3*0)+(2*8)+(1*8)=151
151 % 10 = 1
So 390800-88-1 is a valid CAS Registry Number.
390800-88-1Relevant articles and documents
Process for Preparing and Purifying Bortezomib
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Page/Page column 10, (2012/12/13)
The present invention provides a synthetic process for producing bortezomib using a novel intermediate. The present invention also provides a process for purifying bortezomib anhydride, and a new crystalline polymorph of bortezomib anhydride.
METHODS FOR PREPARING BORTEZOMIB AND INTERMEDIATES USED IN ITS MANUFACTURE
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Page/Page column 14, (2009/03/07)
Provided herein are methods for preparing bortezomib and intermediates useful in the preparation of bortezomib. The present methods unexpectedly provide superior yields and purities, including optical purities, of bortezomib and the intermediates for the preparation of bortezomib.
