39083-19-7Relevant articles and documents
The conversion of amides to esters with Meerwein's reagent. Application to the synthesis of a carfentanil precursor
Kiessling, Anthony J.,McClure, Cynthia K.
, p. 923 - 937 (1997)
An efficient two step transformation of 1°and 2°amides to methyl and ethyl esters has been developed using trimethyl- and triethyloxonium tetrafluoroborates, and dilute acid. This methodology was applied to 1-benzyl-4-phenylamino-4-piperidinecarboxamide, a precursor in the synthesis of carfentanil, to produce the methyl ester in 60% yield and the ethyl ester in 80% yield.
