39101-77-4Relevant academic research and scientific papers
Insights about resveratrol analogs against trypanothione reductase of Leishmania braziliensis: Molecular modeling, computational docking and in vitro antileishmanial studies
da Silva, Adilson D.,dos Santos, Juliana A.,Machado, Patrícia A.,Alves, Lara A.,Laque, Larissa C.,de Souza, Vinícius C.,Coimbra, Elaine S.,Capriles, Priscila V. S. Z.
, p. 2960 - 2969 (2019)
In this work, we combined molecular modeling, computational docking and in vitro analysis to explore the antileishmanial effect of some resveratrol analogs (ResAn), focusing on their pro-oxidant effect. The molecular target was the trypanothione reductase
In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues
Zimmermann-Franco, Danielle Cristina,Esteves, Bruna,Lacerda, Leticia Moroni,Souza, Isabela de Oliveira,Santos, Juliana Alves dos,Pinto, Nícolas de Castro Campos,Scio, Elita,da Silva, Adilson David,Macedo, Gilson Costa
supporting information, p. 4898 - 4906 (2018/09/11)
Resveratrol is a natural polyphenol found mainly on red grapes and in red wine, pointed as an important anti-inflammatory/immunomodulatory molecule. However, its bioavailability problems have limited its use encouraging the search for new alternatives agents. Thus, in this study, we synthetize 12 resveratrol analogues (6 imines, 1 thioimine and 5 hydrazones) and investigated its cytotoxicity, antioxidant activity and in vitro anti-inflammatory/immunomodulatory properties. The most promising compounds were also evaluated in vivo. The results showed that imines presented less cytotoxicity, were more effective than resveratrol on DPPH scavenger and exhibited an anti-inflammatory profile. Among them, the imines with a radical in the para position, on the ring B, not engaged in an intramolecular hydrogen-interaction, showed more prominent anti-inflammatory activity modulating, in vivo, the edema formation, the inflammatory infiltration and cytokine levels. An immunomodulatory activity also was observed in these molecules. Thus, our results suggest that imines with these characteristics presents potential to control inflammatory disorders.
Method for determinng impurity concentration in terephthalic acid
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Paragraph 0011; 0026, (2014/07/23)
The present invention relates to a method for determining the concentration of 4-carboxy benzaldehyde in a terephthalic acid composition, comprising a) reacting 4-carboxy benzaldehyde in the terephthalic acid composition with 2,4-dinitrophenylhydrazine to obtain 4-carboxy benzaldehyde 2,4-dinitrophenylhydrazone and b) determining the concentration of 4-carboxy benzaldehyde 2,4-dinitrophenylhydrazone.
