39102-29-9

Basic information

• Product Name: N-HYDROXY-2-PYRIDIN-2-YL-ACETAMIDINE
• Synonyms: N-HYDROXY-2-PYRIDIN-2-YL-ACETAMIDINE;H31094;(2-Pyridyl)acetamidoxime
• CAS NO: 39102-29-9
• Molecular Formula: C₇H₉N₃O
• Molecular Weight: 151.17
• Product Categories: pharmacetical
• Mol File: 39102-29-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 291.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 14.26±0.50(Predicted)
• CAS DataBase Reference: N-HYDROXY-2-PYRIDIN-2-YL-ACETAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-HYDROXY-2-PYRIDIN-2-YL-ACETAMIDINE(39102-29-9)
• EPA Substance Registry System: N-HYDROXY-2-PYRIDIN-2-YL-ACETAMIDINE(39102-29-9)

Safety Data

• Hazardous Substances Data: 39102-29-9(Hazardous Substances Data)

Usage

General Description

N-HYDROXY-2-PYRIDIN-2-YL-ACETAMIDINE is a chemical compound that is commonly used in pharmaceutical and research applications. It is known for its antiviral and antibacterial properties, making it a valuable ingredient in medications and treatments for various diseases. The compound has also shown potential as a therapeutic agent for neurodegenerative disorders and cancer. Additionally, N-HYDROXY-2-PYRIDIN-2-YL-ACETAMIDINE has been studied for its role in reducing inflammation and oxidative stress in the body. Overall, its diverse pharmacological properties make it a promising compound for further research and development in the medical field.

Upstream product

• 2739-97-1 pyridine-2-acetonitrile 

Downstream Products

• 51119-07-4 2-Acetamidopyrazolo<1,5-a>pyridin 
• 51119-02-9 N-pyrazolo[1,5-a]pyridin-2-yl-benzamide 

Relevant articles and documents

Potent and selective nonpeptidic inhibitors of procollagen C-proteinase

6-Cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-yl)hexanamides were previously disclosed as inhibitors of procollagen C-proteinase (PCP) culminating in the identification of amide 1. Our objective was to discover a second inhibitor that would have improved affinity for PCP and to optimize properties for transepidermal delivery (TED) to intact skin. Further investigation of this template identified a number of potent PCP inhibitors (IC50 values of 2-6 nM) with improved TED flux. Sulfonamide 56 had excellent PCP enzyme activity when measured with a peptide substrate (Ki 8.7 nM) or with the endogenous substrate procollagen (IC50 3.4 nM) and demonstrates excellent selectivity over MMPs involved in wound healing (>10 000-fold). In the fibroplasia model, 56 inhibited deposition of insoluble collagen by 76 ± 2% at 10 μM and was very effective at penetrating human skin in vitro with a TED flux of 1.5 μg/cm2/h, which compares favorably with values for agents that are known to penetrate skin well in vivo. Based on this profile, 56 (UK-421,045) was selected as a candidate for further preclinical evaluation as a topically applied, dermal anti-scarring agent.

Use of naphthalene derivatives in treating lung carcinoma

A method of inhibiting cell growth in human small cell lung carcinoma comprising administering to a mammal in need of such treatment a cell growth inhibitory amount of a compound of the formula STR1

Equilibrium and structural studies on metal complexes of oxime ligands. Formation of copper(II) and nickel(II) complexes of pyridine-2-carboxamidoxime and pyridine-2-acetamidoxime in aqueous solution

The protonation and complex formation equilibria of pyridine-2-carboxamidoxime (HL = 1) and pyridine-2-acetamidoxime (HL = 2) with copper(II) and nickel(II) ions were studied at 25 °C in aqueous 0.1 mol dm-3 NaCl solution by potentiometric titration. Experimental data were analysed with respect to the complexes formed and their stability constants, by using the least-squares computer program SUPERQUAD. In the ligand 1 systems the data for copper(II) can be explained in terms of the mononuclear binary complexes Cu(HL)r2+ (r=1,2) and Cu(HL)L+, and the data for nickel(II) in terms of the stepwise binary complexes Ni(HL)r2+ (r=1,2, 3) together with a series of hydrolysed species HpNi(HL),2+p, where r = 2, 3 and p=1, 2, 3. With ligand 2 the best model for copper(II) was that including the mononuclear complexes Cu(HL)r2+ (r=1,2) and the dimeric species H-2Cu2(HL)22+, and the best model for nickel(II) consisted of the mononuclear complexes Ni(HL)r2+ (r= 1,2) and Ni(HL)L+ together with the dimeric species H-3Ni2(HL)2+. The effect of py substituent in amidoxime compounds was studied by comparing the complex models with those reported earlier for similar aminoamidoxime systems, and it is concluded that the amide group of these py-substituted ligands does not take part in the coordination to the metal. Acta Chemica Scandinavica 1996.