3911-27-1

Usage

Uses

Used in Pharmaceutical Research and Synthesis:
2-(phenyldisulfanyl)ethanaminium chloride is used as an intermediate in the synthesis of various organic compounds for pharmaceutical research and development. Its unique structure and properties contribute to the creation of new drugs and pharmaceutical products.
Used in Organic Chemistry Studies:
In the field of organic chemistry, 2-(phenyldisulfanyl)ethanaminium chloride serves as a valuable reagent in conducting various chemical reactions and experiments, aiding in understanding the behavior of different organic compounds.
Used in Materials Science Development:
2-(phenyldisulfanyl)ethanaminium chloride has potential applications in the development of new materials, leveraging its chemical properties to enhance material characteristics or create novel materials with specific functions.
Used in Organic Chemical Reactions:
As a reagent in organic chemical reactions, 2-(phenyldisulfanyl)ethanaminium chloride facilitates specific transformations and processes, contributing to the advancement of organic synthesis and the production of desired compounds.

Upstream product

• 2127-03-9 2,2'-dipyridyldisulphide 
• 156-57-0 2-mercaptoethylamine hydrochloride 

Relevant academic research and scientific papers

Synthesis, Characterization, and Evaluation of Triptolide Cell-Penetrating Peptide Derivative for Transdermal Delivery of Triptolide

Triptolide (TP) has been used as one of the most common systemic treatments for various diseases since the 1960s. However, TP displays diverse side effects on various organs, which limits its clinical application. To overcome this issue, numerous C-14-hydroxyl group derivatives of TP have been synthesized. In this research, the C-14-hydroxyl group of TP is modified by a cell-penetrating peptide polyarginine (R7). The derivative TP-disulfide-CR7 (TP-S-S-CR7) containing a disulfide linkage between TP and R7 possesses less toxicity at various concentrations on the immortal human keratinocyte (HaCaT) cell line by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay compared with free TP. Treating HaCaT cells with TP (100 nM) could increase intracellular ROS (reactive oxygen species) and decrease the activity of SOD (superoxide dismutase). Meanwhile, treating HaCaT cells with equimolar concentration of TP-S-S-CR7 did not cause both of the above TP-induced alterations. In addition, TP-S-S-CR7 did not show significant dermal toxicity on Guinea pigs and could efficiently overcome the barrier of corneum and then reach epidermis and dermis within 2 h of transdermal administration. In addition, there was a relatively lower concentration of TP in blood indicating less toxicity on organs. Such results suggest that topical therapy using polyarginine is possible by the transdermal delivery of TP.