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1-Methyl-3-(2-methylbenzyl)thiourea is an organic compound with the chemical formula C10H14N2S. It is a derivative of thiourea, featuring a methyl group attached to the nitrogen atom and a 2-methylbenzyl group connected to the other nitrogen atom. 1-methyl-3-(2-methylbenzyl)thiourea is characterized by its white crystalline appearance and is soluble in organic solvents. It is synthesized through the reaction of 2-methylbenzylamine with isothiocyanic acid or its equivalent. 1-Methyl-3-(2-methylbenzyl)thiourea has potential applications in the pharmaceutical industry, particularly as a building block for the synthesis of various biologically active compounds, such as agrochemicals and pharmaceuticals. Its chemical structure and properties make it a versatile intermediate in organic synthesis, allowing for further functionalization and the creation of a diverse range of molecules with potential therapeutic or pesticidal properties.

3911-45-3

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3911-45-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3911-45-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,1 and 1 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3911-45:
(6*3)+(5*9)+(4*1)+(3*1)+(2*4)+(1*5)=83
83 % 10 = 3
So 3911-45-3 is a valid CAS Registry Number.

3911-45-3Downstream Products

3911-45-3Relevant academic research and scientific papers

NOVEL THIOUREA DERIVATIVES AS ACTIVATORS OF RORalpha AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

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Paragraph 0069; 0070; 0077; 0078, (2018/11/02)

Provided is a compound activating RORα gene, particularly a JC1 compound containing CGP52608 thiazolidinedione as a lead substance, and a pharmaceutically acceptable salt thereof. The compound is a lipid accumulation inhibitor and applicable to the treatment of metabolic diseases or inflammatory diseases.

N-methylthioureas as new agonists of retinoic acid receptor-related orphan receptor

Park, Yohan,Hong, Suckchang,Lee, Myungmo,Jung, Hyojun,Cho, Won-Jea,Kim, Eun-Jin,Son, Ho-Young,Lee, Mi-Ock,Park, Hyeung-Geun

, p. 1393 - 1401 (2013/01/15)

Thirty two thiourea derivatives were prepared and their agonistic activities on the retinoic acid receptor-related orphan receptor α (RORα) were evaluated. The replacement of the 3-allyl-2-imino-thiazolidin- 4-one moiety of the lead compound CGP52608 (1) with various functional group substituted aromatic rings, improved the agonistic activity of RORα. Among the prepared derivatives, 1-methyl-3-(4-phenoxy-benzyl)-thiourea (32) showed 2.6-fold higher agonistic activity than CGP52608 in the RORα-activation assay.

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