39115-94-1

Basic information

• Product Name: 3-IODOBENZHYDRAZIDE
• Synonyms: 3-IODO-BENZOIC ACID HYDRAZIDE;3-IODOBENZHYDRAZIDE
• CAS NO: 39115-94-1
• Molecular Formula: C₇H₇IN₂O
• Molecular Weight: 262.05
• Mol File: 39115-94-1.mol
• Article Data: 16

Chemical Properties

• Melting Point: 151-153°C
• Boiling Point: 395.4°Cat760mmHg
• Flash Point: 192.9°C
• Appearance: /
• Density: 1.884g/cm³
• Vapor Pressure: 5.83E-07mmHg at 25°C
• Refractive Index: 1.665
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.97±0.10(Predicted)
• CAS DataBase Reference: 3-IODOBENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODOBENZHYDRAZIDE(39115-94-1)
• EPA Substance Registry System: 3-IODOBENZHYDRAZIDE(39115-94-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 39115-94-1(Hazardous Substances Data)

Usage

General Description

3-Iodobenzhydrazide is a chemical compound that is primarily used in the field of organic chemistry. Its molecular formula is C7H7IN2 and has a molecular weight of 262.05 g/mol. It belongs to the class of chemical compounds known as iodobenzenes, which are organic compounds containing a benzene ring, with an iodine atom in the place of a hydrogen atom; often used in organic synthesis and photovoltaic cells. 3-IODOBENZHYDRAZIDE is particularly useful in synthesis as it acts as a chemical building block or reagent. Like other chemical compounds, it needs to be handled with care and safety as it might have health or environmental hazards.

InChI:InChI=1/C7H7IN2O/c8-6-3-1-2-5(4-6)7(11)10-9/h1-4H,9H2,(H,10,11)

Upstream product

• 625-95-6 3-Iodotoluene 
• 618-51-9 3-Iodobenzoic acid 
• 91487-18-2 2,5-dioxopyrrolidin-1-yl 3-iodobenzoate 
• 58313-23-8 3-iodobenzoic acid methyl ester 
• 618-91-7 methyl 3-iodo-benzoate 

Downstream Products

• 111796-58-8 3-iodo-benzoic acid-(3-iodo-benzhydrylidenehydrazide) 
• 855468-72-3 3-iodo-benzoyl azide 
• 67345-65-7 N-3-iodobenzoyl-N'-(2,2,2-trichloroethylidene) hydrazine 
• 93418-05-4 furfural-(3-iodo-benzoylhydrazone) 
• 690258-13-0 5-ethoxy-3-(3-iodophenyl)-1H-1,2,4-triazole 
• 1544692-16-1 N'-(11H-indeno[1,2-b]quinoxalin-11-ylidene)-3-iodobenzohydrazide 
• 866751-86-2 2,5-bis-(3-iodophenyl)-1,3,4-oxadiazole 

Relevant articles and documents

Identification and optimization of 3-bromo-N’-(4-hydroxybenzylidene)-4-methylbenzohydrazide derivatives as mTOR inhibitors that induce autophagic cell death and apoptosis in triple-negative breast cancer

Triple negative breast cancer (TNBC) has a worse prognosis than other types of breast cancer due to its special biological behavior and clinicopathological characteristics. TNBC cell proliferation and progression to metastasis can be suppressed by inducing cytostatic autophagy. mTOR is closely related to autophagy and is involved in protein synthesis, nutrient metabolism and activating mTOR promotes tumor growth and metastasis. In this paper, we adopted the strategy of structure simplification, aimed to look for novel small-molecule inhibitors of mTOR by pharmacophore-based virtual screening and biological activity determination. We found a lead compound with 3-bromo-N’-(4-hydroxybenzylidene)-4-methylbenzohydrazide for rational drug design and structural modification, then studied its structure-activity relationship. After that, compound 7c with the best TNBC cells inhibitory activities and superior mTOR enzyme inhibitory activity was obtained. In addition, we found that compound 7c could induce autophagic cell death and apoptosis in MDA-MB-231 and MDA-MB-468 cell lines. In conclusion, these findings provide new clues for our 3-bromo-N’-(4-hydroxybenzylidene)-4-methylbenzohydrazide derivatives, which are expected to become drug candidates for the treatment of TNBC in the future.

Synthesis and bioactivity of sulfide derivatives containing 1,3,4-oxadiazole and pyridine

A series of novel sulfide derivatives containing 1,3,4-oxadiazole and pyridine were synthesized, characterized, and tested for their antibacterial activity against tobacco bacterial wilt and rice bacterial blight and for insecticidal activity toward diamondback moth. The results showed that some compounds had good insecticidal and bactericidal activity, e.g., the activities of compounds 6e and 6g–6j toward tobacco bacterial wilt were much better than those of commercial thiodiazole-copper, and some of the synthesized compounds possessed good insecticidal activity against Plutella xylostella. Compounds 6d, 6h, 6j, 6l, 6p, 6r, and 6p displayed over 93% activity at 500 mg L? 1.

Tyrosinase and carbonic anhydrase enzymes inhibition studies of vanadium(V) complexes

Present study endeavors synthesis of series of vanadium(V) hydrazide complexes and its enzyme inhibition studies. Octahedral structure of complexes has been evaluated previously using conductance measurements, spectroscopic techniques involving IR,1H-NMR and13C-NMR, elemental analysis using CHN technique. Complexes 1c-12c have found to exhibit monomeric form with hydrazides behaving as bidentate ligand coordinating by their N and O atoms, while two oxygen atoms have also been found to show attachment with the metal centre. This study includes activity of vanadium(V) complexes to inhibit tyrosinase and carbonic anhydrase enzymes. For inhibition of carbonic anhydrase all, while for tyrosinase most of the hydrazide ligands were found to be inactive. Vanadium(V) complexes with these hydrazides have found to bear variable degree of carbonic anhydrase and tyrosinase inhibition activity. Some of the vanadium(V) hydrazide complexes were found to be potent inhibitors of tyrosinase enzyme and carbonic anhydrase as well.