391225-81-3

Basic information

• Product Name: C₂₅H₁₇Cl₂NO
• Synonyms: C₂₅H₁₇Cl₂NO
• CAS NO: 391225-81-3
• Molecular Weight: 418.322
• Mol File: 391225-81-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₅H₁₇Cl₂NO(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₁₇Cl₂NO(391225-81-3)
• EPA Substance Registry System: C₂₅H₁₇Cl₂NO(391225-81-3)

Safety Data

• Hazardous Substances Data: 391225-81-3(Hazardous Substances Data)

Upstream product

• 22609-02-5 1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)ethanone 
• 104-88-1 4-chlorobenzaldehyde 

Relevant articles and documents

Cu/TEMPO catalyzed dehydrogenative 1,3-dipolar cycloaddition in the synthesis of spirooxindoles as potential antidiabetic agents

A series of spiro-[indoline-3,3′-pyrrolizin/pyrrolidin]-2-ones, 4, 5 and 6 were synthesized in a sequential manner from Cu-TEMPO catalyzed dehydrogenation of alkylated ketones, 1 followed by 1,3-dipolar cycloaddition of azomethine ylides via decarboxylative condensation of isatin, 2 and l-proline/sarcosine, 3 in high regioselectivities and yields. The detailed mechanistic studies were performed to identify the reaction intermediates, which revealed that the reaction proceeds via dehydrogenative cycloaddition. Additionally, the regio and stereochemistry of the synthesized derivatives were affirmed by 2D NMR spectroscopic studies. The synthesized derivatives were explored further with molecular docking, in vitro antioxidant, and anti-diabetic activities.