39136-61-3Relevant academic research and scientific papers
NOVEL KINASE INHIBITORS
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, (2014/05/07)
The present invention provides derivatives of thiazolylamino-substituted heterocycles. These compounds are inhibitors of kinases, including compounds that show antiproliferative activity against cells, including against tumor cells, and are useful in the treatment of diseases including cancer.
IMIDAZO (1, 2-A) PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS
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Page/Page column 23, (2008/06/13)
The present invention provides compounds that are inhibitors of VEGF-R2 of the formula: (I) and methods of using these compounds.
6-thienyl and 6-phenylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase
Andreani, Aldo,Rambaldi, Mirella,Leoni, Alberto,Morigi, Rita,Locatelli, Alessandra,Giorgi, Gianluca,Lenaz, Giorgio,Ghelli, Anna,Degli Esposti, Mauro
, p. 883 - 889 (2007/10/03)
Starting from the potent inhibitory effect of the previously described 2-methyl-6-(2-thienyl)imidazo[2,1-b]thiazole on mitochondrial complex I, we prepared a series of derivatives in order to study the effect of a different substitution at the positions 2, 5 and 6. The replacement of the thienyl group at position 6 with a phenyl group does not modify the biological behaviour of the lead compound, whereas the shift of the methyl group from position 2 to position 5 yields a compound devoid of inhibitory effects. In both the 6-thienyl and 6-phenyl series, the lengthening of the chain at position 2 has provided useful information to outline the structural determinants of the ubiquinone antagonist action in imidazothiazole derivatives.
