39136-62-4Relevant academic research and scientific papers
6-thienyl and 6-phenylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase
Andreani, Aldo,Rambaldi, Mirella,Leoni, Alberto,Morigi, Rita,Locatelli, Alessandra,Giorgi, Gianluca,Lenaz, Giorgio,Ghelli, Anna,Degli Esposti, Mauro
, p. 883 - 889 (2007/10/03)
Starting from the potent inhibitory effect of the previously described 2-methyl-6-(2-thienyl)imidazo[2,1-b]thiazole on mitochondrial complex I, we prepared a series of derivatives in order to study the effect of a different substitution at the positions 2, 5 and 6. The replacement of the thienyl group at position 6 with a phenyl group does not modify the biological behaviour of the lead compound, whereas the shift of the methyl group from position 2 to position 5 yields a compound devoid of inhibitory effects. In both the 6-thienyl and 6-phenyl series, the lengthening of the chain at position 2 has provided useful information to outline the structural determinants of the ubiquinone antagonist action in imidazothiazole derivatives.
