39142-69-3 Usage
Chemical Class
Quinazoline derivatives
Molecular Target
Epidermal Growth Factor Receptor (EGFR) tyrosine kinase
Function
Specific inhibitor of EGFR tyrosine kinase
Potential Application
Anti-cancer agent
Mechanism of Action
Inhibits the proliferation of cancer cells, especially in cases with EGFR overexpression
Role in Cancer Therapy
Targeted therapy for various types of cancer
Structure-Function Relationship
The unique structure of PD153035 allows it to effectively target and inhibit EGFR tyrosine kinase, making it a promising candidate for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 39142-69-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,1,4 and 2 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 39142-69:
(7*3)+(6*9)+(5*1)+(4*4)+(3*2)+(2*6)+(1*9)=123
123 % 10 = 3
So 39142-69-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H15N3O/c1-14-7-2-5-11-18(14)23-19(15-8-6-12-21-13-15)22-17-10-4-3-9-16(17)20(23)24/h2-13H,1H3
39142-69-3Relevant academic research and scientific papers
An efficient synthesis of 2,3-diaryl (3H)-quinazolin-4-ones via imidoyl chlorides
Kalusa, Andrew,Chessum, Nicola,Jones, Keith
experimental part, p. 5840 - 5842 (2009/04/05)
A practical and efficient three step synthetic route to 2,3-diaryl (3H)-quinazolin-4-ones has been developed. The key step involves microwave-assisted condensation of an imidoyl chloride with an aryl amine. This methodology affords the products cleanly and in high yields.
