3915-25-1Relevant academic research and scientific papers
A convenient and highly stereoselective synthesis of 4α-deuterio and -tritio steroids catalyzed by Pd
Rabinowitz
, p. 6081 - 6084 (2007/10/02)
A simple and highly stereoselective synthesis of [4α-2H]- and [4α-3H]-Δ5-3β-hydroxysteroids is presented. Palladium(O)-mediated borodeuteride reduction of readily-available cholest-5-en-3β,4β-diol cyclic carbonate provides [4α-2H]-Δ5-and Δ4-cholesterol in a 12:1 ratio. Reduction of [4α-3H]-cholest-5-ene-3β,4β-diol cyclic carbonate with NaB1H4 and Pd(O) resulted in [4β-3H]-cholesterol.
