391677-19-3

Upstream product

• 391677-15-9 (2R,3S,4S)-3-((S)-2-Hydroxy-but-3-enyl)-4-isopropenyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 391677-13-7 (3S,3aS,5S,7aR)-3-Isopropenyl-7-oxo-5-vinyl-hexahydro-pyrano[3,4-b]pyrrole-1-carboxylic acid benzyl ester 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 120229-02-9 (2R,3S,4S)-4-Isopropenyl-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 

Relevant academic research and scientific papers

Intramolecular ene reaction on a bicyclo[3.2.1]octane system: An alternative route to (-)-kainic acid

The intramolecular ene reaction of the 1,6-diene on a bicyclo[3.2.1]octane framework proceeds in a highly diastereoselective manner to form a trisubstituted pyrrolidine on the pyran ring in excellent yield. Its stereochemistry has been determined unambiguously by converting it into the known compound serving as a key intermediate of (-)-kainic acid.