391678-52-7

Basic information

• Product Name: Carbamic acid, [1,1-bis(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [1,1-bis(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester (9CI)
• CAS NO: 391678-52-7
• Molecular Formula: C₁₀H₂₁NO₄
• Molecular Weight: 219.27804
• Product Categories: N-BOC
• Mol File: 391678-52-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [1,1-bis(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [1,1-bis(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester (9CI)(391678-52-7)
• EPA Substance Registry System: Carbamic acid, [1,1-bis(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester (9CI)(391678-52-7)

Safety Data

• Hazardous Substances Data: 391678-52-7(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 115-70-8 2-ethyl-2-amino-propane-1,3-diol 

Downstream Products

• 566938-31-6 (4R)-ethyl-4-[2-(furan-2-yl)ethyl]-1,3-oxazolidin-2-one 
• 566938-27-0 (4R)-ethyl-4-[2-(furan-2-yl)ethenyl]-1,3-oxazolidin-2-one 
• 1401995-59-2 2-(tert-butoxycarbonyl)amino-2-ethyl-3-hydroxylpropyl dibenzyl phosphate 

Relevant articles and documents

AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.

Nonenzymatic enantioselective monoacetylation of prochiral 2-protectedamino-2-alkyl-1,3-propanediols utilizing a chiral sulfonamide-Zn complex catalyst

Treatment of a chiral sulfonamide with Et2Zn gave quantitatively its Zn complex and then the structure was determined by X-ray crystallographic analysis. Reaction of prochiral W-Boc-2-amino-2-alkyl-1,3-propanediols with Ac2O in the presence of 5 mol% of chiral sulfonamide - Zn complex catalyst afforded the corresponding chiral monoacetyl products in 70-92% yields with 70-88% ee values. The proposed mechanism for the catalytic monoacetylation of a prochiral 1,3-propanediol was presented on the basis of CSI-MS analysis.