391683-75-3

Upstream product

• 140860-88-4 2-fluoro-5-(4-fluorophenyl)-3-(trifluoromethyl)furan 
• 873-75-6 4-bromobenzenemethanol 
• 391683-63-9 2-(4-bromobenzyloxy)-5-(4-fluorophenyl)-3-trifluoromethylfuran 

Relevant academic research and scientific papers

Domino reactions with 2-fluoro-3-trifluoromethylfurans and -thiophenes [1]

The single fluorine atom of 2-fluoro-3-trifluoromethylfurans and -thiophenes can be readily replaced by various nucleophiles. Depending on the substituent pattern, certain products obtained upon nucleophilic substitution with benzyl alcohols are susceptible to [1,3]- and [1,5]-benzyl group migrations under very mild conditions. Therefore, these rearrangements can be integrated into domino reactions.